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Received:February 25, 2020 Published Online:December 20, 2020
Received:February 25, 2020 Published Online:December 20, 2020
中文摘要: 目的 研究非小细胞肺癌(NSCLC)患者胸腔积液中细胞角蛋白片段21-1(CYFRA21-1)与可溶性血管内皮生长因子受体-1(sVEGFR-1)表达的变化及其临床意义。方法 选取2017年1月至2018年1月收治的合并胸腔积液的NSCLC患者80例,对所有患者行无菌胸腔穿刺取患者胸腔积液,并抽取静脉血,分离取上清液,采用免疫电化学发光法检测患者胸腔积液及血清中CYFRA21-1表达水平,采用酶联免疫吸附试验法检测患者胸腔积液及血清中sVEGFR-1表达水平。用Pearson相关性分析CYFRA21-1、sVEGFR-1之间的相关性。结果 在NSCLC患者胸腔积液中,CYFRA21-1的表达水平高于患者血清表达水平(P<0.01),sVEGFR-1的表达水平低于患者血清表达水平(P<0.01)。在Ⅲ期~Ⅳ期、肺鳞癌、死亡组患者胸腔积液中,CYFRA21-1的表达水平分别高于Ⅰ期~Ⅱ期、肺腺癌、存活组患者(P<0.01),sVEGFR-1的表达水平分别低于Ⅰ期~Ⅱ期、肺腺癌、存活组患者(P<0.01)。Pearson相关性分析显示,CYFRA21-1与sVEGFR-1的表达水平呈负相关(r=-0.390,P<0.01)。结论 在NSCLC患者胸腔积液中,CYFRA21-1高表达,sVEGFR-1低表达,且均与患者病理分期、肿瘤类型相关,两者呈负相关。
中文关键词: 非小细胞肺癌 胸腔积液 细胞角蛋白片段21-1 可溶性血管内皮生长因子受体-1
Abstract:Objective To study the expressions and clinical significance of cytokeratin 19 fragment 21-1(CYFRA21-1) and soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) in pleural effusion of the patients with non-small cell lung cancer (NSCLC). Methods Eighty NSCLC patients with pleural effusion admitted to hospital from January 2017 to January 2018 were selected, in whom the pleural effusion was obtained with aseptic pleural puncture, and the supernatant was separated from venous blood samples.The expression levels of CYFRA21-1 and sVEGFR-1 in pleural effusion and serum were detected respectively by ELISA.Pearson correlation was used to analyze the relationship between CYFRA21-1 and sVEGFR-1. Results In pleural effusion of NSCLC patients, the level of CYFRA21-1 was significantly higher than that in serum of NSCLC patients, and the level of sVEGFR-1 was lower than that in serum of NSCLC patients (P<0.01).The levels of CYFRA21-1 in pleural effusion of stage Ⅲ-Ⅳ NSCLC, squamous- cell lung carcinoma and dead patients were significantly higher than those in stage Ⅰ-Ⅱ NSCLC, adenocarcinoma and survival patients (all P<0.01).Pearson correlation analysis showed that CYFRA21-1 was negatively correlated with sVEGFR-1(r=-0.390, P<0.01). Conclusion In NSCLC patients, high expression of CYFRA21-1 and low expression of VEGFR-1 in pleural effusion are correlated with pathological stage and tumor type, and there is a negative correlation between CYFRA21-1 and VEGFR-1.
keywords: Non-small cell lung cancer Pleural effusion Cytokeratin fragment 21-1 Soluble vascular endothelial growth factor receptor-1
文章编号: 中图分类号:R734.2 文献标志码:B
基金项目:西安市科技计划项目(2017113SF/YX007-4)
Author Name | Affiliation |
ZHOU Jing, LI Suo-ni, JIAO Mi, GUO Ya-huan, ZHENG Qi | Department of Medicine, Shaanxi Provincial Cancer Hospital, Xi′an, Shaanxi 710061, China |
Author Name | Affiliation |
ZHOU Jing, LI Suo-ni, JIAO Mi, GUO Ya-huan, ZHENG Qi | Department of Medicine, Shaanxi Provincial Cancer Hospital, Xi′an, Shaanxi 710061, China |
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