Abstract:Objective To investigate the effects of fructose diphosphate oral solution combined with Saccharomyces boulardii sachets on serum IgA,IgG,TNF-α,IL-6 levels and myocardial injury in children with rotavirus enteritis(RVE).Methods A total of 104 children with RVE admitted to hospital between August 2017 and August 2019 were randomly divided into the control group and the combined group ( n=52,each).Based on the conventional symptomatic treatment plus Saccharomyces boulardii sachets oral administration for 7 days in both groups,fructose sodium diphosphate was given in combined group.The clinical efficacy,serum IgA,IgG,inflammatory factors,myocardial injury indexes and adverse reactions were observed between two groups.Results The total effective rate was significantly higher in combined group than that in control group (94.23% vs 76.92%, P<0.05).Compared with those before treatment,the levels of enterobacteriaceae,TNF-α,IL-6,CK,CK-MB,LDH and AST decreased in two groups after treatment and were lower in combined group than those in control group ( P<0.05, P<0.01);the contents of bifidobacterium,lactobacillus ,serum IgA and IgG increased in two groups and were significantly higher in combined group than those in control group( P<0.05, P <0.01).There was no statistical difference in the incidence of adverse reactions between two groups (7.69% vs 17.31%, P >0.05),even though it was slightly lower in combined group.ConclusionFructose sodium diphosphate combined with Saccharomyces boulardii sachets can inhibit inflammatory processes,alleviate myocardial damage,improve body metabolism and intestinal microecology,which have high safety in RVE children.