Abstract:Objective To observe the effects of incision infiltration with dexmedetomidine and ropivacaine on postoperative analgesia in patients after posterior lumbar fusion． Methods Sixty patients who underwent posterior spinal fusion surgery from January to December 2019 were randomly divided into group R,group D1and group D2 (n=20,each).For local infiltration before incision suture closure,0.5% ropivacaine 30 ml was given in group R;1.0 μg/kg dexmedetomidine with same dose of ropivacaine was used in group D1;1.5 μg/kg dexmedetomidine with same dose of ropivacaine was used in group D2. Recovery time from anesthesia, PACU stay time, and the occurrence of bradycardia, hypotension and excessive sedation were recorded; the VAS scores of the patients of three groups were compared at 4, 8, 12, 24 and 48 hours after operation. The first time required for analgesics,the cases of required remedial analgesia,the number of analgesia pump pressing at 24 h and 48 h after operation and the occurrence of nausea,vomiting and vertigo were observed and recorded. Results There were no cases of excessive sedation in three groups and no significant differences in recovery time,PACU stay time and the incidence of bradycardia and hypotension among three groups (all P>0.05).Compared with group R,VAS scores significantly decreased at 8-,12-,24- hour after operation in group D1 and at 8-,12-,24- and 48-hour after operation in group D2 (all P<0.05);the first time required for analgesics delayed in other two groups,and was statistically later in group D2 than that in group D1(all P＜0.05);the incidence of salvage analgesia was lower in group D1 and group D2(all P<0.0167),and the number of the analgesic pump pressing at 24 h and 48 h in group D1 and group D2 decreased (all P<0.05). There was no statistical difference in the incidence of postoperative nausea,vomiting and vertigo among the three groups (all P>0.05). Conclusion In posterior lumbar fusion,local infiltration of dexmedetomidine (1.0、1.5 μg/kg)combined with ropivacaine can prolong the active time of ropivacaine,effectively relieve postoperative pain and reduce the amount of postoperative analgesic consumption.