Abstract:Objective To investigate the clinical characteristics of sepsis in pregnancy and puerperium and the maternal and fetal prognosis. Methods A retrospective analysis was performed in the clinical data of sepsis patients admitted to the obstetrics department of Shenzhen People′s Hospital from November 2003 to November 2018 to study the clinical features of sepsis and evaluate the prognosis of mother and infant. Results Out of 20 subjects with an average age of (30.3±4.36) years, there were 10 cases of sepsis during pregnancy and 10 cases of puerperal sepsis.Twin pregnancy accounted for 15.0%, and multipara accounted for 70%, more than primipara.The primary infection foci were mainly urinary tract infection(50.0%), and reproductive tract infection, digestive system infection and urinary system infection accounted for 15.0% respectively. Escherichia coli was the most common bacteria in the results of biological culture, accounting for 42.1%.The most common sensitive antibiotics for Escherichia coli were piperacillin/tazobactam and meropenem.The most common antibiotics of drug-resistant were ceftriaxone, cefotaxime and cefuroxime axetil.In most patients (90%) treated with β-lactam antibiotics, 3 patients received surgical intervention.Of 20 patients, 14 were cured, 4 were died, and 2 were lost to follow-up.There were 2 cases of abortion and 1 case of stillbirth. Conclusion Sepsis in pregnancy and puerperium is one of the important causes of maternal mortality.The most common source of infection was respiratory tract infection, followed by reproductive tract infection, digestive system infection and urinary system infection.Early identification, empirical antibiotic therapy, timely adjustment of antibiotics based on drug susceptibility test results and appropriate surgical interventions play important roles in reducing adverse maternal and infant outcomes.