Abstract:Objective To analyze the risk factors of coronary artery calcification (CAC) and the relationship between serum preptin level and CAC in the patients with coronary heart disease. Methods A total of 110 coronary heart disease patients diagnosed by coronary CT angiography (CTA) from January 2018 to June 2019 were selected as study subjects.According to Agatston coronary artery calcium score (CACS),the patients were divided into non-calcification group (CACS=0) and calcification group (CACS>0).Questionnaire survey and physical examination were performed,and serum biochemical indicators and Preptin level were detected.Student′s t-test and χ2 test were used for single factor analysis of risk factors for CAC;Logistic regression was used to determine the risk factors associated with CAC. Results Univariate analysis showed that the incidence of hypertension and diabetes,age and the level of Pretin in calcification group were statistically higher than those in non-calcification group (P<0.05,P<0.01).Based on the regression model［Logit(P)=3.130+0.069×age+0.880×hypertension+0.812×diabetes+0.093×Preptin］,Logistic regression analysis showed that high level of Preprin,old age,hypertension and diabetes history were the independent risk factors of CAC (OR=1.756,1.152,1.753,1.408,respectively,P<0.05 or P<0.01). Conclusions The level of serum Preptin in coronary heart disease patients with CAC is obviously higher than that in patients without calcification.The increased level of serum Preptin is a risk factor for CAC and may be an important indicator for the diagnosis of CAC.