Abstract:Objective To investigate the relationship between plasma soluble low-density lipoprotein receptor-related protein-1(sLRP-1),serum regulated upon activation normal T cell expressed and secreted (RANTES) and Global Registry of Acute Coronary Events(GRACE) score in the patients with acute coronary syndrome (ACS) and further analyze their impacts on 30 d major adverse cardiac event(MACE). Methods A total of 120 ACS patients were selected,in whom plasma sLRP-1 and serum RANTES levels were detected by ELISA.Based on the risk assessment and stratification of GRACE scores,the patients were divided into high-risk group(GRACE score>140),medium-risk group(109-140) and low-risk group(<109).The statistical analysis was carried out with lg sLRP-1(μg/ml) in a normal distribution after lg conversion.According to the median value of lg sLRP-1 and RANTES,the patients were divided into high lg sLRP-1 group (>0.54 μg/ml),low lg sLRP-1 group (≤0.54 μg/ml),and high RANTES group (>125.47 pg/ml),low RANTES group (≤125.47 pg/ml),respectively.The associations of sLRP-1 and RANTES levels with GRACE scores and prognosis were analyzed and evaluated. Results The levels of lg sLRP-1 and RANTES were significantly elevated in high-risk group compared with those in medium-risk group and low-risk group (all P<0.05).GRACE scores in high lg sLRP-1 group and high RANTES group were statistically higher than those in low lg sLRP-1 group and low RANTES group,respectively(all P<0.01).GRACE score was positively correlated with lg sLRP-1 and RANTES levels,respectively(r=0.460,P<0.05;r=0.626,P<0.05).In terms of lg sLRP-1,RANTES,GRACE score and the combination of the three predicting 30 d MACE,the area under the ROC curve(AUC) were 0.875,0.787,0.820 and 0.924,respectively,and AUC of the combination of three was the highest(P<0.05). Conclusions The sLRP-1 and RANTES are associated with the progress of ACS.Detection of sLRP-1 and RANTES combined with GRACE scores can better reflect the risk stratification of ACS patients.