Abstract:Objecitve By a retrospective analysis of upper urinary tract stone composition, to explore its correlation with blood uric acid levels and provide scientific basis for early prevention and reasonable treatment. Methods A total of 150 urinary stone samples were collected by ureteroscopic (soft) lithotripsy and percutaneous nephrolithotripsy performed in urology department of Chongming Branch of Xinhua Hospital Affiliated to Shanghai Jiaotong University Medical College from January 2017 to June 2018.Qualitative analysis of stone composition was made by infrared spectrum, and the level of blood uric acid was determined by reagent method. Results Of 150 specimens, 77 were simple stones and 73 were mixed stones.In stone composition, there were 109 calcium oxalate stones, 83 ammonium phosphate stones, 45 carbonate apatite, 17 uric acid stones and 6 cysteine stones.The level of blood uric acid elevated in 121 cases.The increased rate of blood uric acid changed with different stone components:uric acid stone (100.00%), calcium oxalate (81.65%), magnesium ammonium phosphate (72.29%), carbonate apatite (53.33%), cystine stone (50.00%).There were significant differences between the patients with stone of carbonate apatite and those with stones of magnesium ammonium phosphate, calcium oxalate and uric acid stones (P<0.05) and between the patients with stone of magnesium ammonium phosphate and those with uric acid stone (P<0.05).The recurrence rate and the residual stone removal rate in the patients with acid-reducing therapy were slightly higher than those with routine follow-up visit, but there was no statistical difference. Conclusion Non uric acid calculus is related to the elevation of blood uric acid level, and changing the state of high uric acid level may help to control the occurrence and progress of urinary stones in upper urinary tract.