Abstract:Objecitve To investigate the effect of proton pump inhibitors (PPIs) on intestinal bacterial overgrowth (SIBO) in patients with reflux esophagitis (RE) and the corrective effect of bifidobacteria. Methods A total of 100 RE patients who received treatment at Deyang people′s Hospital from January 2017 to December 2018 were selected as RE group, and 60 healthy volunteers in the same period were selected as the control group.SIBO was diagnosed by lactulose hydrogen breath test (LHBT).According to the treatment, RE group was divided into group A (oral PPIs+bifidobacterium) and group B (oral PPIs only) with 50 cases each.The treatment time was one month.The fecal flora before treatment and one month after treatment were compared between the two groups. Results There was no significant difference in the positive rate of SIBO between RE group and control group before treatment [12.0%(12/100) vs 10.0%(6/60), P>0.05].The positive rate of SIBO in RE group was higher after the treatment [53.0%(53/100) vs 12.0%(12/100), P<0.05].The number of bifidobacteriacteria and lactobacilli in feces of RE group was significantly lower than that of control group (P<0.01).The number of Staphylococcus in fecal flora of Re Group was significantly higher than that of control group(P<0.01).The number of bifidobacteria and lactobacilli in group A was significantly higher than that in group B (P<0.05).The number of Escherichia coli and Staphylococcus in group A was significantly lower than that in group B (P<0.05). Conclusion After long-term use of PPIs, the positive rate of Sibo in RE patients was significantly increased, and bifidobacteria and lactobacilli were reduced.The combination of bifidobacterium can correct the imbalance of intestinal flora caused by PPIs.