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Received:September 12, 2019 Published Online:May 20, 2020
Received:September 12, 2019 Published Online:May 20, 2020
中文摘要: 目的 探讨氨溴索联合鼻塞式持续气道正压(CPAP)通气治疗对新生儿肺炎患儿血气指标、凝血功能的影响。方法 将2018年2月至2019年5月接受治疗的92例新生儿肺炎患儿随机分为观察组和对照组（各46例）。对照组给予鼻塞式CPAP治疗,观察组在对照组基础上给予氨溴索治疗。对比两组的疗效,检测两组患儿治疗前后血气指标［氧分压(PaO2)、二氧化碳分压(PaCO2)、氧合指数］和凝血功能［活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶原时间(PT)］。结果 观察组的总有效率高于对照组（95.65%vs80.43%,P<0.05)。观察组的退热时间、止咳时间、肺部阴影消失时间、住院时间显著短于对照组(P<0.01)。治疗后两组的PaCO2较治疗前降低,PaO2、氧合指数升高,且观察组优于对照组(P<0.01)。治疗后两组的APTT、PT较治疗前缩短,FIB升高,且观察组优于对照组(P<0.01)。结论 在鼻塞式CPAP治疗基础上,给予氨溴索可进一步提高新生儿肺炎的疗效,改善患儿血气指标和凝血功能。
Abstract:ObjectiveTo investigate the impacts of ambroxol combined with continuous positive airway pressure (CPAP) on blood gas index and coagulation function in newborn infants with pneumonia.MethodsNinety-two cases of neonatal pneumonia from February 2018 to May 2019 were randomly divided into observation group and control group (n=46,each).The nasal CPAP was performed in control group,and ambroxol was added in observation group based on nasal CPAP.Blood gas index ［arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2),oxygenation index］ and coagulation function ［activated partial thromboplastin time (APTT),fibrinogen (FIB),prothrombin time (PT)］ were measured before and after treatment to compare the curative effect between two groups.ResultsThe total effective rate in observation group was higher than that in control group (95.65% vs 80.43%,P<0.05).The antipyretic time,cough relief time,pulmonary shadow disappearance time and hospitalization time in observation group were significantly shorter than those in control group (P<0.05).After treatment,PaCO2 decreased,PaO2 and oxygenation index increased significantly,APT and PT decreased,and FIB increased significantly in both groups (P<0.01),and these indexes in observation group were significantly improved compared with control group（P<0.01）.ConclusionOn the basis of nasal CPAP,ambroxol can further improve the blood gas index and coagulation function with better curative effect for neonatal pneumonia.
keywords: Neonatal pneumonia Ambroxol Continuous positive airway pressure Blood gas index Coagulation function
文章编号： 中图分类号： 文献标志码：B
基金项目:河北省卫生和计生委员会2018年度医学科学研究重点课题(20180852)
| Author Name | Affiliation |
| LIANG Jun-xia,YUAN Er-wei | Department of Neonatology,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China |
| Author Name | Affiliation |
| LIANG Jun-xia,YUAN Er-wei | Department of Neonatology,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China |
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