Abstract:ObjectiveTo investigate the clinical efficacy,safety and adverse reactions of oral propranolol for the treatment of infantile hemangiomas.MethodsA total of 101 children with hemangioma admitted to the Dermatology Ward of the Xinjiang Uygur Autonomous Region People′s Hospital from December 2015 to December 2017 were enrolled and given oral propranolol 0.5-2 mg·kg-1·d-1after excluding contraindications.The changes of heart rate,blood pressure and blood glucose were monitored before and after medication.During monthly in-hospital and follow-up for at least 6 months,the dosage of propranolol was adjusted according to body weight,and the volume change of hemangioma was recorded to observe the efficacy,safety and adverse reactions.ResultsIn the curative efficacy,there were 5 cases of grade Ⅰ(poor),3 cases of grade Ⅱ(medium),13 cases of grade Ⅲ(good) and 80 cases of grade Ⅳ(excellent).The effective rate(grade Ⅲ+grade Ⅳ) was 92.08%,and the tumor rebounded in 4 cases after drug withdrawal.During the treatment,there were some adverse reactions such as hypotension,loose stool,hypoglycemia and upper respiratory tract infection,most of which occurred in the early stage of medication and were improved after follow-up or symptomatic treatment.ConclusionOral propranolol is effective in the treatment of infantile hemangiomas and has obvious curative effect in some children with less adverse reactions,however,it needs to be taken under strict monitoring to ensure safety.