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中国临床研究英文版:2020,33(5):623-625,629
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应激性高血糖及白细胞计数升高对急性脑梗死近期预后的影响
(1.华北理工大学附属医院神经内科,河北 唐山063000;2.华北理工大学,河北 唐山063000)
Influences of stress hyperglycemia and leukocyte count on the short-term prognosis of acute cerebral infarction
摘要
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Received:August 20, 2019   Published Online:May 20, 2020
中文摘要: 目的 探讨应激性高血糖及白细胞计数升高对急性脑梗死(ACI)患者近期预后的影响。方法 收集2011年1月至2018年12月ACI患者1 102例患者的临床资料,随访发病2周时的预后情况。采用单因素和多因素Logistic回归分析,对应激性高血糖、白细胞数异常对ACI预后的影响进行分析。结果 (1)控制混杂因素的影响后,当血糖水平高于6.1 mmol/L时,患者预后不良发生的危险性增加了0.753倍;当血糖水平高于8.5 mmol/L时,患者预后不良发生的危险性增加了2.592倍;当血糖水平高于10.5 mmol/L时,患者预后不良发生的危险性增加了4.576倍。(2)控制混杂因素的影响后,当白细胞数水平高于10×109/L时,患者预后不良发生的危险性增加了0.708倍;当白细胞数水平高于14×109/L时,危险性则增加5.599倍;当白细胞水平高于18×109/L时,危险性增加6.847倍。(3)控制其他混杂因素的影响后,当同时存在应激性高血糖和白细胞数升高时,急性脑梗死患者预后不良的危险性显著增加(P<0.01)。结论 应激性高血糖、白细胞计数升高是急性脑梗死预后不良的危险因素。
Abstract:ObjectiveTo explore the impacts of stress hyperglycemia and leukocyte count on the short-term prognosis of patients with acute cerebral infarction (ACI).MethodsThe clinical data of 1 102 patients with ACI from January 2011 to December 2018 were collected,including prognosis of patients in two weeks after onset.Single-factor and multi-factor logistic regression analysis were used to analyze the influences of stress hyperglycemia and abnormal leukocyte count on the prognosis of ACI.Results(1)After adjusting some confounding factors,the risk of poor prognosis increased to 1.753 [JP2]times as blood glucose level was more than >6.1mmol/L,3.592 times as blood glucose level was more than >8.5 mmol/L,[JP]and 5.576 times as blood glucose level was higher than 10.5 mmol/L.(2)After controlling for the influence of confounding factors,the risk of poor prognosis increased to 1.708 times when the level of leukocyte was higher than 10 × 109/L,6.599 times when the level of leukocyte was higher than 14×109/L and 7.847 times when the level of leukocyte was higher than 18×109/L.(3)When stress hyperglycemia and elevated leukocyte count existed simultaneously,the risk of poor prognosis increased significantly(P<0.01).ConclusionsStress hyperglycemia and elevated leukocyte count are the risk factors of poor short-term prognosis in patients with acute cerebral infarction.
文章编号:     中图分类号:    文献标志码:B
基金项目:河北省2020年度医学科学研究课题计划(20201238)
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