Abstract:Objective To investigate the effect of Jinshuibao capsule combined with chemotherapy regimen containing cycloserine on immune function in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB). Methods Eighty MDR-TB patients treated from January 2015 to January 2016 were divided into observation group and control group (n=40,each).The chemotherapy regimen containing cycloserine,namely 6Am-Z-Lfx-Cs-Pto/18Z-Lfx-Cs-Pto was performed in control group,and Jinshuibao capsule was used in observation group on the basis of 6Am-Z-Lfx-Cs-Pto/18Z-Lfx-Cs-Pto. The curative effect of traditional Chinese medicine(TCM) on the cavity and focus were compared between two groups.The levels of CD3⁺,CD4⁺,CD8⁺,CD4⁺/CD8⁺,NK cells were detected before and after treatment,and the adverse reactions were observed during the treatment in two groups. Results There was no significant difference in TCM curative effect,cavity curative effect and focus curative effect between two groups (all P>0.05). After treatment,the CD3⁺,CD4⁺,CD4⁺/CD8⁺,and NK cells in observation group increased significantly and were higher than those in the control group;CD8⁺decreased significantly and was lower than that in control group (all P<0.05). The incidence of adverse reactions in observation group was significantly lower than that in control group (10.0% vs 27.5%,P<0.05). ConclusionJinshuibao capsule combined with the chemotherapy regimen containing cycloserine can improve the immune function of patients with MDR-TB and reduce the incidence of adverse reactions.