Abstract:Objective To evaluate the functional and structural changes of left atrium (LA), left atrial appendage (LAA) and left ventricle (LV) in patients with atrial fibrillation (AF) by using Philips Brilliance iCT to analyze the relationship between each structure and AF and to provide favorable imaging data for clinic. Methods A retrospective analysis was performed for the clinical iCT images of 20 patients with confirmed AF (AF group) and 20 patients (control group) with negative computed tomographic angiography(CTA) from August 2018 to October 2018. Using the post-processing workstation software, the left atrial maximum volume (LAV^max), left atrial minimum volume (LAV^min), left atrial appendage maximum volume (LAAV^max), left atrial appendage minimum volume (LAAV^min), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV) and left ventricular myocardium mass (LVMass) were measured respectively in two groups. and the left atrial ejection fraction (LAEF), left atrial appendage fraction (LAAEF), and left ventricular ejection fraction (LVEF) were calculated. According to whether there was thrombus or prethrombotic state in left atrial appendage, AF group was divided into positive AF subgroup and negative AF subgroup; according to clinical diagnosis, AF group was divided into persistent AF subgroup and paroxysmal AF subgroup. Correlation statistical analysis was made on the structural and functional data of left atrium, left auricle and left ventricle. Results LAV^max, LAV^min, LAAV^max, LAAV^min, LVESV and LVMass in AF group were significantly higher than those in control group, and LAEF, LAAEF, LVEF were lower than those in control group (all P<0. 05). LAV^max, LAV^min, LAAV^max, LAAV^min, LVESV and LVMass in persistent AF subgroup were significantly higher than those in paroxysmal AF subgroup, and LAEF, LAAEF, LVEF were significantly lower than those in paroxysmal AF subgroup(all P<0. 05), however, there was no statistical difference in LVEDV between two subgroups(P>0. 05). LAV^max, LAV^min, LAAV^max and LAAV^min in thrombotic-positive AF subgroup were higher than those in thrombotic-negative AF subgroup (P<0. 05), LAEF, LAAEF, and LVEF were lower than those in thrombotic-negative AF subgroup (all P<0. 05), and there were no significant differences in LVEDV, LVESV and LVMass between two subgroups (all P>0. 05). Conclusion In the patients with persistent AF and positive thrombus, the structural and functional remodeling of left atrium, left atrial appendage and left ventricle appeared more obviously.