Abstract:Objective To investigate the effect of perioperative intravenous lidocaine infusion on postoperative pain and rapid recovery in patients undergoing radical cystectomy.Methods A total of 108 adult patients undergoing open radical cystectomy from September 2017 to October 2018 were randomly divided into lidocaine group (L group) and control group (C group,n=54,each).After induction of tracheal intubation by general anesthesia,lidocaine ( 2 mg/min ) and normal saline were respectively administered intravenously for 4 hours in lidocaine group and control group.The first time of exhaust and defecation,time of resuming regular diet,hospital stay,satisfaction of patients and incidence of perioperative complications were evaluated and observed in both groups.The numerical rating scale (NRS) on resting state at 2,4,6,12,24,48 and 72h after surgery were recorded,and the chronic postsurgical pain (CPSP) were assessed at 3 and 6 months by brief pain inventory (BPI).Results There were 3 patients lost in the followup period,1 in L group and 2 in C group.The first time of exhaust and defecation,time of recovering normal diet and hospital stay in L group were significantly shorter than those in C group,and the patients′ satisfaction was significantly better than that in C group (P<0.01).NRS scores on resting state in L group were statistically lower than those in C group at 2,4,6 and 12h after surgery (P<0.05),but there were no significant differences at 24,48,72h after operation between two groups(P>0.05).NRS score and the incidence of CPSP in L group were significantly lower than those in C group at 3 and 6 months postoperatively (P<0.01).The incidence of perioperative complications were similar in two groups (P>0.05).Conclusion For the patients receiving radical cystectomy,perioperative intravenous lidocaine infusion can promote the recovery of gastrointestinal function and reduce the degree of postoperative acute pain and has a positive effect on the longterm prognosis of CPSP after radical cystectomy.