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Received:May 05, 2019 Published Online:January 20, 2020
Received:May 05, 2019 Published Online:January 20, 2020
中文摘要: 目的 探讨调肝运脾法联合美沙拉嗪缓释颗粒治疗腹泻型肠易激综合征(IBS-D)的临床疗效。
方法 2016年9月至2017年11月诊治的200例IBS-D患者根据随机数字表法分为两组,各100例。对照组采用美沙拉嗪缓释颗粒治疗,观察组采用调肝运脾法联合美沙拉嗪缓释颗粒治疗,疗程2周。比较两组疗效、IBS 症状严重程度量表(IBS-SSS)、 IBS 生活质量量表 (IBS-QOL)评分的差异。
结果 观察组临床治愈率(51.00% vs 35.00%,P=0.022)、总有效率(98.00% vs 81.00%,P=0.000)均高于对照组;观察组治疗后IBS-SSS评分由(261.04±76.08)降到(122.81±13.81),治疗前后差异具有统计学意义(P=0.000),且观察组治疗后低于对照组治疗后(P=0.000);观察组治疗后除自体意象外IBS-QOL各维度评分显著低于治疗前(P均<0.01),且IBS-QOL所有维度评分观察组治疗后均低于对照组治疗后(P均<0.01)。
结论 调肝运脾法联合美沙拉嗪缓释颗粒治疗IBS-D效果优于美沙拉嗪。
中文关键词: 调肝运脾法 美沙拉嗪缓释颗粒 肠易激综合征,腹泻型
Abstract:Objective To explore the clinical efficacy of Tiaogan Yunpi method combined with mesalazine sustained-release granules on diarrhea-predominate irritable bowel syndrome(D-IBS).
Methods Total 200 patients with D-IBS were divided into two groups according to the random number table method from September 2016 to November 2017.The control group(n=100) was treated with mesalazine sustained-release granules,and the observation group (n=100) was treated with Tiaogan Yunpi method combined with mesalazine sustained-release granules.The course of treatment was 2 weeks,and the differences in the efficacy,IBS Symptom Severity Scale (IBS-SSS),and IBS Quality of Life Scale (IBS-QOL) scores were compared between the two groups.
Results The cure rate (51.00% vs 35.00%,P=0.022) and total effective rate (98.00% vs 81.00%,P=0.000) in the observation group were higher than those in the control group.After treatment,the IBS-SSS score of the observation group decreased from (261.04±76.08) to (122.81±13.81)(P<0.01),and was lower than that of the control group.Except for self-intention,the scores of other dimensions of IBS-QOL in the observation group after treatment were significantly lower than those before treatment(all P<0.01),and the scores of all dimensions of IBS-QOL in the observation group after treatment were lower than those in the control group(all P<0.01).
Conclusion Tiaogan Yunpi method combined with mesalazine sustained-release granules is better than mesalazine in treating diarrhea-type irritable bowel syndrome.
keywords: Tiaogan Yunpi method Mesalazine sustained-release granules Irritable bowel syndrome,diarrhea type
文章编号: 中图分类号: 文献标志码:B
基金项目:江苏省研究生科研与实践创新计划项目(SJCX18_[KG-*4]0457)
Author Name | Affiliation |
XU Wen-hui, LI Lei | The Second Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210017,China Corresponding author:LI Lei,E-mail:455790172@qq.com |
Author Name | Affiliation |
XU Wen-hui, LI Lei | The Second Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210017,China Corresponding author:LI Lei,E-mail:455790172@qq.com |
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