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Received:May 06, 2019 Published Online:January 20, 2020
Received:May 06, 2019 Published Online:January 20, 2020
中文摘要: 目的 探讨绝经后骨质疏松妇女血清白细胞介素(IL)-33水平变化及其临床意义。
方法 选取2019年1月至4月在徐州医科大学附属邳州医院骨科门诊就诊的绝经后骨质疏松症患者50例为观察组,同期健康体检的绝经后妇女50例为对照组。采用酶联免疫吸附法检测两组患者血清中IL-33水平。
结果 与健康体检组相比较,绝经后骨质疏松患者血清IL-33水平明显降低［(5.43±2.48)pg/ml vs (20.12±3.44) pg/ml,P<0.01］。
结论 绝经后骨质疏松妇女血清IL-33水平较健康人显著降低,IL-33可能是一种重要的骨保护细胞因子,对诊治绝经后骨质疏松症有一定的指导作用。
Abstract:Objective To explore the changes of serum interleukin-33 (IL-33) in women with postmenopausal osteoporosis (PMOP)and its clinical significance.
Methods Fifty patients with PMOP admitting to Orthopedic Department of Pizhou Hospital Affiliated to Xuzhou Medical University from January to April 2019 were selected as observation group,and 50 healthy postmenopausal women were served as control group at the same period.By enzyme linked immunosorbent assay (ELISA),the serum level of IL-33 was detected in two groups.
Results Compared with control group,the serum IL-33 level significantly decreased in observation group ［(5.43 ± 2.48) pg/ml vs (20.12±3.44) pg/ml,P<0.01］.
Conclusions The serum level of IL-33 in women with PMOP is significantly lower than that in healthy postmenopausal women.IL-33 may be an important cytokine of bone protection and has a certain guiding role in the treatment of PMOP.
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基金项目:徐州医科大学校级科研课题项目资助(2018KJ23);徐州医科大学附属邳州医院2019年院科研基金(2019KY001)
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