Abstract:Objective To compare the clinical effect and safety between single-incision and three-port video-assisted thoracoscopic surgery(VATS) in the treatment of early-stage lung cancer. Methods Out of 114 cases of early lung cancer reviewed from July 2017 to March 2019 retrospectively,there were 46 patients receiving single-incision VATS (single-incision group) and 68 patients undergoing conventional three-port VATS (three-port group).The operation time,blood loss,hemostasis time,number of lymph node cleaning,postoperative chest tube drainage duration,total thoracic drainage volume,postoperative hospital stay,pulmonary complications,pain degree and neurological symptoms were compared between two groups. Results The operation time,hemostasis time,postoperative chest tube drainage duration,total pleural drainage volume,postoperative hospital stay,VAS score and sensory abnormality rate at one month after operation in single-incision group were significantly better than those in three-port group (P<0.05,P<0.01).However,there were no statistical differences in blood loss,number of lymph node cleaning,pulmonary complications,postoperative arrhythmia and postoperative VAS score at one day after surgery,after extubation and at discharge between two groups (all P>0.05). Conclusion Single-incision VATS has better clinical effect and safety in the treatment of early-stage lung cancer compared with three-port VATS.