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Received:April 28, 2019 Published Online:January 20, 2020
Received:April 28, 2019 Published Online:January 20, 2020
中文摘要: 目的 探讨2型糖尿病和结直肠癌患者淋巴结转移的关系。
方法 收集重庆医科大学附属第一医院2016年1月1日至2017年7月1日符合纳入标准的1 624例结直肠癌患者进行回顾性病例对照研究,分析其中合并2型糖尿病患者(n=208)与未合并糖尿病患者(n=1 416)的淋巴结转移情况。统计学检验水准取α=0.05,当采用R×C表χ2检验分割法时,检验水准调整为α′=0.017。
结果 淋巴结转移者638例,合并糖尿病组中96例,非糖尿病组中542例,糖尿病组结直肠癌淋巴结转移率高于非糖尿病组(46.2% vs 38.3%,P=0.030)。糖尿病组208例中长期糖尿病患者(糖尿病病程>2年)152例,短期糖尿病患者(糖尿病病程≤2年组)56例,长期糖尿病患者淋巴结转移率高于非糖尿病组(48.7% vs 38.3%,P<0.017)。淋巴结转移率在T3~T4期糖尿病患者(n=157)为56.1%,在T3~T4期非糖尿病患者(n=1 074)为44.6%,在T1~T2期糖尿病患者(n=51)为15.7 %,在T1~T2期非糖尿病患者(n=342)为18.4 %;糖尿病T3~T4期淋巴结转移率高于糖尿病T1~T2期(P<0.017)。
结论 合并糖尿病、尤其是糖尿病病程大于2年的结直肠癌患者淋巴结转移的风险增高。T分期较高的结直肠癌患者淋巴结转移风险较高,但尚未显示糖尿病对不同T分期患者淋巴转移率有统计学意义的影响,有待进一步研究。
Abstract:Objective To investigate the relationship between type 2 diabetes mellitus (T2DM) and lymph node metastasis in patients with colorectal cancer.
Methods A total of 1 624 patients with colorectal cancer in the First Affiliated Hospital of Chongqing Medical University from January 2016 to July 2017 were collected for a retrospective case-control study,in order to analyze the lymph node metastasis of patients with T2DM (n=208) and non-T2DM (n=1 416).The statistical test standard was α=0.05.When the partitioning chi-squared test of R×C table was used,the test standard was adjusted to α ′=0.017.
Results There were 638 cases of lymph node metastasis,96 cases in the T2DM group and 542 cases in the non-T2DM group.The lymph node metastasis rate in the T2DM group was higher than that in the non- T2DM group (46.2% vs 38.3%,P=0.030).In the T2DM group(n=208),there were 152 patients with medium and long-term T2DM (course of T2DM >2 years),56 patients with short-term T2DM (course of T2DM≤2 years).The lymph node metastasis rate of long-term T2DM patients was higher than that of non-T2DM patients (48.7% vs 38.3%,P<0.017).The lymph node metastasis rate was 56.1% in T3-T4 T2DM patients (n=157),44.6% in T3-T4 non-T2DM patients (n=1 074),15.7% in T1-T2 T2DM patients (n=51),18.4% in T1-T2 non-T2DM patients (n=342).The lymph node metastasis rate was higher in T3-T4 T2DM patients than that in T1-T2 T2DM patients (P<0.017).
Conclusions The risk of lymph node metastasis is higher in patients with diabetes mellitus,especially in colorectal cancer with a diabetes course of more than 2 years.The risk of lymph node metastasis in colorectal cancer patients with high T stage is higher,but it has not been shown a statistically significant impact of diabete on the lymph node metastasis rate in different T stage patients,which needs further study.
keywords: Colorectal cancer Lymph node metastasis Diabetes mellitus Course of diabetes mellitus T stage
文章编号: 中图分类号: 文献标志码:A
基金项目:
Author Name | Affiliation |
PENG Xu-lin,XIANG Zheng | Department of Gastrointestinal Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China |
Author Name | Affiliation |
PENG Xu-lin,XIANG Zheng | Department of Gastrointestinal Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China |
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