Abstract:Objective To systematically evaluate the efficacy and safety of laparoscopic right hepatectomy (LRH) and open right hepatectomy (ORH) for the treatment of liver tumors. Methods The PubMed,Embase,the Cochrane Library,CNKI,and Wanfang databases were searched by computer,and randomized or non-randomized ontrolled trials comparing the efficacy of LRH with ORH in the trecatment of liver tumors were collected.After screening the literature,extracting the data and evaluating the quality according to the Cochrane systematic review method,statistical analysis was performed using Rev Man 5.3.Continuous variables were calculated by mean difference (MD) and 95% confidence interval (CI),while binary variables were calculated by odds ratio (OR) and 95%CI. Results A total of 8 case-control studies,but no randomized controlled trials(RCT) were included,with a total of 591 patients(219 in the LRH group and 372 in the ORH group).Meta-analysis showed:compared with the ORH group,the LRH group had less intraoperative blood loss,lower incidence of postoperative complications,and shorter hospital stay(P<0.05,P<0.01);the operation time of LRH group was longer than that of ORH group(P<0.05).During follow-up of patients with liver malignant tumors,there was no significant difference in the 1-year survival rate and 2-year survival rate between the LRH group and the ORH group (all P>0.05). Conclusions LRH is safe and feasible in liver surgery.Although the operation time of LRH is longer than that of ORH group,but LRH has the characteristics of less trauma,less intraoperative blood loss,lower incidence of postoperative complications and shorter hospital stay,and has no significant difference with ORH in 1-year survival rate and 2-year survival rate.Due to limitations in the number and quality of included studies,the above conclusions need to be further validated with large sample and high quality clinical RCTs.