Abstract:Objective To investigate the effect of thoracoscopy combined with laparoscopy on thoracic esophageal cancer and its influence on lung function,erythrocyte immunity and cellular immunity. Methods A total of 95 patients who were diagnosed as thoracic esophageal cancer in the Fifth People′s Hospital of Qinghai Province from February 2017 to March 2019 were selected as study objects.According to the needs of the patients and their own conditions,the patients were divided into the observation group (n=50) and the control group (n=45).The control group was operated by traditional esophageal cancer resection,and the observation group was operated under the assistance of thoracoscopy and laparoscopy.The lung function,erythrocyte immunity,cellular immunity and serum trauma indexes of the two groups were compared before and after treatment. Results The pulmonary function indexes of all patients were improved significantly after treatment (all P<0.05).After treatment,vital capacity (VC),forced expiratory volume in first second (FEV1) and maximal voluntary ventilation (MVV) decreased in both groups,while VC,FEV1 and MVV of the control group were significantly lower than those of the observation group (all P<0.01).At the end of the operation,RBC-TRR and RBC-C3bRR in the observation group were significantly decreased (P<0.05),and RBC-ICR increased (P<0.05)；RBC-TRR and RBC-C3bRR re-increased and RBC-ICR re-decreased 1 day after operation,and all three indexes recovered to preoperative level 3 days after operation.The RBC-C3bRR and RBC-TRR of the observation group were significantly higher than those of the control group,and RBC-ICR of the observation group was significantly lower than that of the control group (P<0.01).At the end of the operation,CD3⁺,CD4⁺ and CD4⁺/CD8⁺ in the observation group were lower than those before treatment (P<0.05),and gradually increased on the first day after operation and recovered to the preoperative level on the third day after operation.There was significant difference between two group at each time point after operation (all P<0.05).At the end of operation,the levels of prostaglandin E2 (PGE2),interleukin (IL)-6 and cortisol (Cor) in the observation group were significantly higher than those before the treatment (P<0.05).There was significant difference between two group at each time point after operation (all P<0.01). ConclusionThoracoscopy combined with laparoscopy may have little effect on lung function and cellular immunity in patients who need to receive radical operation of thoracic esophageal cancer,and can significantly reduce perioperative injury.