Abstract:Objective To investigate the effect of total hip arthroplasty(THA) via small incision posterolateral approach on the patients with femoral neck fracture. Methods A total of 120 patients with femoral neck fractures from July 2015 to July 2018 were enrolled and divided into experimental group and control group according to different treatment method(n=60,each).The small incision posterolateral approach for total hip arthroplasty was performed in experimental group,and the conventional incision posterior approach for total hip arthroplasty was conducted in control group.The operation-related indexes and the incidence of postoperative complications were compared between two groups.Serum inflammatory factors ［interleukin-6 (IL-6),C-reactive protein (CRP)］ before and 1-,14- day after operation,bone metabolic indexes ［amino-terminal propeptide of type I procollagen (PINP),tartrate-resistant acid phosphatase 5b (TRACP-5b)］ before and one month after operation and hip joint function before and 6 months after operation were observed and compared between two groups. Results There was no significant difference in operation time between two groups (P>0.05).Compared with control group,the intraoperative blood loss,the postoperative drainage and the hospital stay statistically decreased in experimental group (all P<0.05).At 1 day after operation,the levels of serum IL-6 and CRP in two groups were significantly higher than those before operation and were statistically lower in experimental group than those in control group (P<0.05);at 14 days after operation,the levels of IL-6 and CRP in two groups were significantly lower than those before operation and 1 day after operation (P<0.05),but there was no significant difference between two groups (P>0.05).The levels of serum PINP and TRACP-5b in experimental group were significantly improved 1 month after operation,and PNP level increased,and TRACP-5b level decreased significantly compared with control group (P<0.05).There was no significant difference in the postoperative complication rate between experimental group and control group (8.33% vs 15.00%,P>0.05).At 6 months after operation,the scores of hip joint function were significantly higher than those before operation in experimental group and were significantly higher than those in control group (P<0.05). ConclusionFor the patients with femoral neck fracture,posterolateralmini-incisiontotalhiparthroplastycan significantly reduce intraoperative blood loss,postoperative drainage volume and serum inflammatory factor levels,promote fracture healing and hip function recovery and improve the quality of life of patients.