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Received:May 15, 2019 Published Online:December 23, 2019
Received:May 15, 2019 Published Online:December 23, 2019
中文摘要: 目的 探讨急性大动脉粥样硬化型脑梗死患者血清胆固醇与外周血自然杀伤细胞(NK细胞)的关系。方法 选取2017年5月至2018年5月在开封市中心医院住院的神经内科的急性大动脉粥样硬化型脑梗死患者63例作为观察组,另取同期在本院进行体检的健康人38例作为正常对照组;两组分别应用流式细胞仪直接免疫荧光染色法检测外周血NK细胞水平及全自动生化分析仪检测血清胆固醇值,对比两组间的差异,并行相关性分析。结果 观察组患者血清胆固醇值标高于正常对照组,差异有统计学意义(P<0.05),同时外周血NK细胞值的水平亦明显高于正常的对照组,差异有统计学意义(P<0.01),经Pearson相关性分析发现,急性大动脉粥样硬化型脑梗死患者血清胆固醇与外周血NK细胞水平呈正相关性(r=0.179,P=0.011)。结论 急性大动脉粥样硬化型脑梗死患者发病后外周血NK细胞水平与血清胆固醇值具有明显相关性,可为寻找新的调脂药物提供临床依据。
Abstract:ObjectiveTo investigate the relationship between serum cholesterol and natural killer cells (NK cells) in patients with acute atherosclerotic cerebral infarction. Methods Sixty-three patients with acute large atherosclerotic cerebral infarction (TOAST classification) hospitalized in the department of neurology of Kaifeng Central Hospital from May 2017 to May 2018 were selected as the study subjects (observation group),and 38 healthy physical examinee were served as normal control group at the same time.Using flow cytometry direct immunofluorescence staining and automatic biochemical analyzer,the levels of peripheral blood NK cells and serum cholesterol were respectively detected and were compared between two groups.The related analysis was made. Results The levels of serum cholesterol and NK cells in peripheral blood in observation group were statistically higher than those in control group (P<0.05,P<0.01).Pearson test showed that there was a positive correlation between serum cholesterol level and peripheral blood NK cell level in patients with acute atherosclerotic cerebral infarction (r=0.179,P=0.011). ConclusionIn patients with acute atherosclerotic cerebral infarction,there is a significant correlation between the level of peripheral blood NK cells and serum cholesterol level,which can provide clinical basis for finding new lipid-regulating drugs.
文章编号: 中图分类号:R 743.33 文献标志码:A
基金项目:河南省科技厅科技攻关项目(182102310445)
Author Name | Affiliation |
LIU Ning,XU Jian-ke,ZHANG Hong-yang,GAO Cheng-en,HAN Xin-sheng | Department of Neurology,Kaifeng Central Hospital in Henan Province,Kaifeng,Henan 475000,China |
Author Name | Affiliation |
LIU Ning,XU Jian-ke,ZHANG Hong-yang,GAO Cheng-en,HAN Xin-sheng | Department of Neurology,Kaifeng Central Hospital in Henan Province,Kaifeng,Henan 475000,China |
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