Abstract:Objective To explore the clinical value of neutrophil to lymphocyte ratio（NLR）combined with amino-terminal pro-brain natriuretic peptide (NT-proBNP) in the short-term prognosis of patients with chronic heart failure (CHF). Methods CHF patients admitting to the Cardiovascular Department of Fenyang Hospital from September 2016 to May 2018 were enrolled.According to whether there were major cardiovascular events (MACE) occurring in 1-year follow-up,the patients were divided into MACE group (n=68) and non MACE group (n=55).The levels of NLR,NT-proBNP,WBC,hemoglobin,creatinine and blood glucose were detected and compared between two groups.Using non-invasive cardiac hemodynamic monitor,left ventricular ejection fraction (LVEF),systolic index (IC),pulmonary capillary wedge pressure (PCWP) were measured and compared between two groups.Pearson correlation analysis and multivariate logistic regression analysis were used to analyze the risk factors related to the incidence of MACE in CHF patients.The receiver operator characteristic (ROC) curve was used to analyze the best predictive value of NLR combined with NT-proBNP for patient′s prognosis. Results Compared with non MACE group,NLR,NT-proBNP increased significantly,albumin and LVEF decreased significantly in MACE group (P<0.05,P<0.01),while there were no significant differences in WBC,hemoglobin,creatinine,IC and PCWP between two groups (P>0.05).Pearson correlation analysis showed that NLR,NT-proBNP,albumin and LVEF were correlated with the incidence of MACE(P<0.05,P<0.01).Multivariate logistic regression analysis showed that NLR and NT-proBNP were the independent predictors of MACE(P<0.01).ROC curve analysis showed that plasma NLR ≤2.330 and NT-proBNP≤2 749 pg/mL were the best predictive cut-off points for the occurrence of MACE(AUC=0.933，P<0.01；AUC=0.716，P<0.01). ConclusionNLR combined with NT-proBNP can better predict the short-term prognosis of CHF patients.