Abstract:Objective To investigate the diagnostic significance of serum tumor makers ［carcinoembryonic antigen (CEA),tumor specific growth factor (TSGF),carbohydrate antigen (CA)153,osteopontin (OPN)］ in undetermined breast nodules,and the combined detection of the above four serological indicators and mammogram in the diagnosis of breast nodules. Methods A total of 131 patients who hospitalized for breast nodules in Tangshan People′s Hospital from January 2013 to December 2017 were selected as study objects.All patients received venous blood tests for CEA,TSGF,CA153,OPN and molybdenum target mammogram at admission,and finally confirmed the pathological results by needle core biopsy.The changes of serum tumor markers and mammogram and the positive rate of diagnosis in breast nodules were compared. Results Among 131 patients,61 were benign breast nodules and 70 were malignant breast nodules.The serum CEA,TSGF,CA153 and OPN of malignant breast nodule group were higher than those of benign breast nodule group (all P<0.05),but there were no significant differences in CEA,TSGF,CA153 and OPN of different breast cancer types (all P>0.05).The positive rate of CEA,TSGF,CA153,OPN combined with mammogram (61.43%) was significantly higher than that of the above indices detected alone (all P<0.05). Conclusion CEA,TSGF,CA153 and OPN are important indicators for the diagnosis of benign and malignant breast nodules,and combined with molybdenum target mammogram can improve the positive rate of diagnosis of malignant breast nodules,which is conducive to early diagnosis and treatment of breast cancer.