Abstract:Objective To compare the predictive value of C-reactive protein(CRP),prealbumin (PA),neutrophil-lymphocyte count ratio (NLCR) and fibrinogen (FIB) level for bacterial infection in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 117 patients with AECOPD treated from November 2017 to November 2018 were selected as study subjects and divided into bacteria infection group (n=48) and non-bacteria infection group (n=69) according to the golden standard of sputum bacteria culture results.After collecting venous blood,the contents of serum CRP and PA,NLCR and FIB level were respectively detected by immuno-projection turbidimetry,automatic hematology analyzer and photoelectromagnetic method. Results Serum CRP content and NLCR in bacteria infection group were higher than those in non-bacteria infection group,while serum PA content and FIB level were lower than those in non-bacteria infection group (all P<0.01).Receiver operating characteristic(ROC) curve,drawed for predictive value of the indicators,showed that area under ROC curve (AUC) and cut-off value were 0.884 and 163.789 mg/L for serum PA,0.881and 47.037 mg/L for serum CRP,0.861 and 4.071 for NLCR,0.777 and 3.704 g/L for FIB,respectively. Conclusion CRP,PA,NLCR and FIB have high predictive value for bacterial infection in patients with AECOPD,and PA has the highest predictive value,followed by CRP,NLCR and FIB.