Abstract:Objective To investigate and compare the influences of on-pump and off-pump coronary artery bypass grafting(CABG) surgery on renal function in patients with coronary heart disease(CHD) complicated with renal dysfunction. Methods A total of 120 CHD patients with renal dysfunction undergoing CABG surgery were recruited in this study and were randomly divided into off-pump CABG group and on-pump CABG group(n=60,each).The renal functions were monitored and compared at 12 hours,1-,3- and 5- day after surgery.The post-operative situations,including intubation time,ICU hospital stay,blood transfusion volume,total hospitalization time and incidence of complications were compared between two groups. Results The serum creatinine (Cr) levels were similar at 12 hours after operation between two groups (P>0.05),but were significantly higher in on-pump group than those in off-pump group at 1-,3- and 5-day after operation (all P<0.05).The incidence of renal replacement therapy in on-pump group was significantly higher than that in off-pump group ［7/60(11.67%) vs 1/60(1.67%),P<0.05)］.The time of tracheal intubation,ICU stay and total hospitalization in on-pump group were significantly longer than those in off-pump group (all P<0.05).There were no significant differences in blood transfusion volume and the proportions of atrial fibrillation and secondary thoracotomy between two groups (P>0.05).The infection rate in on-pump group was significantly higher than that in off-pump group (P<0.05).None of the patients died in hospital after operation. Conclusion Compared to on-pump CABG,off-pump CABG could reduce the risk of post-operative renal replacement therapy and infection and promote postoperative recovery in CHD patients with renal dysfunction.