Abstract:Objective To investigate the risk factors of acute renal injury (AKI) in patients with ovarian cancer who were treated with cisplatin as the main chemotherapy regimen. Methods A retrospective analysis was made of 98 patients who were hospitalized in Changzhou No.2 People′s Hospital from May 2017 to September 2018 and received the first round of cisplatin-based chemotherapy.According to whether AKI occurred after cisplatin treatment, the patients were divided into AKI group and non-AKI group.The differences of clinical characteristics between two groups were analyzed.Logistic regression analysis was carried out to explore the independent risk factors of AKI in ovarian cancer patients treated with cisplatin as the main chemotherapy regimen. Results AKI occurred in 19 of 98 patients (19.4%).There were significant differences in diabetes mellitus, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) and radiocontrast agent between AKI group and non-AKI group (P<0.05).Logistic regression analysis showed that ACEI/ARB (OR=4.718, 95%CI:1.290-17.254, P=0.019) and contrast medium (OR=6.277, 95%CI:1.411-27.916, P=0.016) were independent risk factors for cisplatin induced AKI. Conclusion Taking ACEI/ARB and using contrast agent are independent risk factors for AKI in ovarian cancer patients with cisplatin-based chemotherapy regimen.