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Received:August 14, 2018 Published Online:March 20, 2019
Received:August 14, 2018 Published Online:March 20, 2019
中文摘要: 目的 研究分析气道黏液高分泌对慢性阻塞性肺疾病急性加重期(AECOPD)患者预后及炎症因子的影响。方法 选择2014年9月至2017年9月在呼吸内科住院的AECOPD患者225例进行回顾性分析,根据是否存在气道黏液高分泌分为两组,高分泌组110例,非高分泌组115例。对两组患者相关指标进行对比分析,包括预后相关因素即住院时间、6 min步行距离、1年内急性发作次数,肺功能包括1秒用力呼气容积(FEV1)、1秒用力呼气容积占用力肺活量百分比(FEV1/FVC)、1秒用力呼气容积占预计值百分比(FEV1%Pred)、呼气峰值流速占预计值百分比(PEF%Pred),及白介素6(IL-6)、白介素8(IL-8)、降钙素原(PCT)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)等炎症指标。结果 高分泌组住院时间、6 min步行距离、1年内急性发作次数均明显高于非高分泌组,差异有统计学意义(P<0.01)。高分泌组的FEV1、FEV1/FVC、FEV1%、PEF%Pred均低于非高分泌组(P<0.05,P<0.01)。高分泌组TNF-α、PCT、CRP、IL-6、IL-8水平均高于非高分泌组(P<0.05,P<0.01)。结论 存在气道黏液高分泌的AECOPD患者预后较差,血清炎症因子水平更高。
中文关键词: 慢性阻塞性肺疾病,急性加重期 气道黏液高分泌 白细胞介素6 白细胞介素8 肿瘤坏死因子
Abstract:Objective To study the impacts of airway mucus hypersecretion on prognosis and inflammatory factors in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A retrospective analysis of 225 patients with AECOPD admitted to the Department of Respiratory Medicine from September 2014 to September 2017 was performed.According to airway mucus secretion, the patients were divided into hypersecretion group (n=110) and non-hypersecretion group (n=115).Comparative analysis was made between two groups on the next indexes:related-prognosis indicators including hospital stay, 6-minute walking distance, number of acute attacks within one year; indicators of lung function including forced expiratory volume in 1 second (FEV1) , the ratio of FEV1 to forced vital capacity (FVC) (FEV1/FVC) , FEV1% predicted, peak expiratory flow (PEF) values expressed as a percentage of their predicted value (PEF% Pred) ; inflammatory markers including interleukin (IL) -6, IL-8, procalcitonin (PCT) , C-reactive protein (CRP) , tumor necrosis factor (TNF) -α. Results The hospitalization time, 6-minute walking distance and the number of acute episodes within one year in hypersecretion group were significantly higher than those in non-hypersecretion group.Values of FEV1, FEV1/FVC, FEV1%Pred, PEF% Pred were significantly lower in hypersecretion group than those in non-hypersecretion group (P<0.05, P<0.01).Levels of PCT, IL-6, IL-8, TNF-α and CRP in hypersecretion group were statistically higher than those in non-hypersecretion group (P<0.05, P<0.01). Conclusion AECOPD patients with airway mucus hypersecretion have a poorer prognosis and a higher level of serum inflammatory factors.
keywords: Chronic obstructive pulmonary disease, acute exacerbation Airway mucus hypersecretion Interleukin-6 Interleukin-8 Tumor necrosis factor
文章编号： 中图分类号： 文献标志码：A
基金项目:河南省基础与前沿技术研究计划项目（B20140032）
| Author Name | Affiliation |
| FU Xiao-xiao, HAN Xiao-peng, LIU Jian-bo | Department of Respiratory Medicine, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, China |
| Author Name | Affiliation |
| FU Xiao-xiao, HAN Xiao-peng, LIU Jian-bo | Department of Respiratory Medicine, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, China |
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