Abstract:Objective? To analyze the high risk factors of central venous catheter line-associated bloodstream infection (CLABSI) in intensive care unit (ICU).? Methods A retrospective analysis was performed in 252 patients with central venous catheterization (CVC) in ICU of three hospitals from April 2016 to April 2017. According to whether CLABSI occurred or not, the patients were divided into infection group (n=22) and non-infection group (n=230). The related factors such as catheter infection rate per one thousand days, catheter flora, time and site of catheter placement were statistically organized and analyzed.? Results The infection rate of CLABSI was 8.73% (22/252), and the infection rate per one thousand days was 2.61‰. Bacterial culture founded 11 strains (50.00%) of Gram-negative bacilli, 9 strains (40.91%) of Gram-positive cocci and 1 strain (4.55%) of Candida albicans in central venous catheter tip, and/or catheter blood and peripheral venous blood. One patient with CLABSI presented negative culture results. Univariate analysis showed that catheterization time, antibiotics use before catheterization and incidence of complicating with diabetes mellitus in infection group were significantly higher than those in non-infection group (P<0.05, P<0.01), however, there were no significant differences in catheterization site and tracheal intubation between two groups (all P>0.05). Logistic regression analysis showed that catheterization time more than 14 days (OR=3.094), antibiotics use before catheterization (OR=4.157) and complicating with diabetes mellitus (OR=3.332) statistically increased the probability of developing CLABSI in CVC patients (P<0.05, P<0.01).? Conclusion The high risk factors of CLABSI in ICU are mainly related to catheterization time for more than 14 days, antibiotics use before catheterization and complicating with diabetes mellitus. To reduce the incidence of CLABSI in ICU effectively, the targeted intervention should be taken in clinic.