Abstract:Abstract:ObjectiveTo investigate the efficacy of octreotide associated with gastroscope intervention in the treatment of peptic ulcer with upper gastrointestinal hemorrhage and its influence on serum gastrin and hemoglobin level. MethodsA total of 114 patients with peptic ulcer and upper gastrointestinal hemorrhage who received treatment from July 2015 to December 2017 were selected and divided into treatment group and control group randomly (n=57 each). The control group patients received base treatment and gastroscope intervention, and the treatment group was treated with octreotide on the basis of control group. The clinical efficacy, pH value of fasting gastric juice, re bleeding rate, converting operation rate, level of serum gastrin and hemoglobin, time of occult blood turning negative and discharge time were observed and compared in two groups. ResultsThe total effective rate in treatment group was higher than that in control group (96.49% vs 80.70%, χ²=7.033, P=0.008). After the treatment, the pH value of fasting gastric juice in both groups were higher than those before the treatment, and pH value in treatment group was higher than that in control group (all P<0.01). The rebleeding rate and converting operation rate in treatment group were lower than those in control group (all P<0.01). The level of serum gastrin was lower and hemoglobin was higher after the treatment in both groups, and there were significant differences in two groups (all P<0.01). The time of occult blood turning negative and discharge time were [(4.61±1.42)d, (7.35±2.18)d] shorter in treatment group compared with control group [(6.83±2.06)d, (10.14±3.29)d, P<0.05)]. ConclusionIn the treatment of peptic ulcer with upper gastrointestinal hemorrhage, octreotide associated with gastroscope intervention could improve clinical efficacy and the level of serum gastrin and hemoglobin. 