Abstract:Objective To investigate the clinicopathological features and treatment methods of primary malignant melanoma of female vulva. Methods The clinical data of 12 female patients with primary malignant melanoma of vulva who received treatment in Baoji Maternity and Child Health Hospital from June 2000 to December 2016 were analyzed retrospectively. Results There were 9 cases of vulvar mass, 3 cases of vulvar ulceration or bleeding, 6 cases of vulvar pruritus, 4 cases of grown-up mole, 4 cases of obvious pigmentation, 3 cases of vulvar ulcer. The lesion diameter was less than 2 cm in 9 cases and more than 2 cm in 3 cases. According to the international union of obstetrics and gynecology (FIGO), there were 6 cases in stage Ⅰ, 3 cases in stage Ⅱ, and 3 in stage Ⅲ. All patients were treated with surgery operation, and some of them were combined with treatment of immunization and chemotherapy. The inguinal lymphadenectomy was performed in 8 cases, and metastasis occurred in 3 cases. Three patients survived for less than 1 year, 1 patient survived for 1-2 years, 6 patients for 5-10 years, and 2 patients survived for 10 years. Conclusion The individualized surgical treatment should be given in female patients with primary malignant melanoma of vulva, supplemented by chemotherapy and immunotherapy when necessary.