Abstract:Objective To evaluate the clinical value of venous blood gas analysis in predicting the prognosis of patients with diabetic ketoacidosis. Methods A total of 108 patients with diabetic ketoacidosis hospitalized in intensive care unit(ICU) were selected and received routine ICU admission. Blood gas analysis was performed within 48 hours after onset. Patients were followed up for 28 days. According to the prognosis during follow-up, the patients were enrolled in survival group (improved or were not deteriorated, n=92) and in death group (n=16). The partial pressure of oxygen (PO₂), partial pressure of carbon dioxide (PCO₂), pH value, bicarbonate ion (HCO₃^-), base excess (BE) were measured and compared between two groups, and the correlation between the above indicators and the acute physiology and chronic health status scoring system (APACHE Ⅱ) were analyzed. Results The levels of PCO₂, HCO₃^-, BE and APACHEⅡ score in survival group were significantly lower than those in death group (all P<0.05), but there were no significant differences in PO₂ and pH value between two groups (P>0.05). Receive operator characteristic (ROC)curve showed that area under curves (AUC) of BE and APACHE Ⅱ score were the largest, suggesting the highest diagnosis rate of BE and APACHE Ⅱ score for diabetic ketoacidosis prognosis. Pearson correlation analysis showed that BE was positively correlated with APACHEⅡ score (r=0. 584, P=0. 007), namely, the lower the level of BE in blood of patients with diabetic ketoacidosis, the lower APACHEⅡ score. Conclusions Venous blood gas analysis has the advantage of simple operation. For patients with diabetic ketoacidosis, early venous blood gas analysis is beneficial to judging the prognosis. The lower the level of blood BE, the lower the APACHE II score, the better the prognosis.