Abstract:Objective To investigate the risk factors of urosepsis after ureteroscopic lithotripsy. Methods A total of 251 patients who received ureteroscopic lithotripsy from July 2016 to December 2017 were retrospectively analyzed. According to the occurrence of urosepsis, the patients were divided into urosepsis group (n=12, 4. 8%) and no urosepsis group (n=239). The patients′ age, BMI, gender, diabetes, anatomic malformation, chronic renal insufficiency, preoperative double J stent, recent history of lithiasis fever, bilateral surgery, operation time, and signs of infection were investigated, single and multiple factor analysis were used to analyze the risk factors of urosepsis after ureteroscopic lithotripsy. Results Single factor analysis showed that there was no significant difference between the two groups in age, BMI, gender, diabetes, preoperative double-J stent retention and operation time (all P>0.05). However, the incidence rate of renal anatomical malformation, chronic renal insufficiency, the recent history of lithiasis fever, bilateral operation and infection in the urosepsis group were significant higher than those in the no urosepsis group (P<0.05, P<0.01). Multiple factor analysis showed that the preoperative absence of double-J tube (P=0. 02), recent history of lithiasis fever (P=0. 00) and indications of intraoperative infection (P=0. 00) were independent risk factors for the occurrence of urosepsis. Conclusion The risk factors for the occurrence of urosepsis after ureteroscopic lithotripsy include the preoperative absence of double-J stent, the recent history of lithiasis fever and the signs of intraoperative infection.