Abstract:Objective To investigate the effect of curve-top guidewire (loach guidewire) and ultra-smooth hydrophilic guidewire (zebra guidewire) in super-selective intubation of intrahepatic bile duct in endoscopic retrograde cholangiopancreatography (ERCP).? Methods A total of 100 patients who needed selective intubation of intrahepatic bile duct from January 2015 to June 2016 were selected as study object, and they were divided into loach guidewire group and zebra guidewire group by random digits table method (50 cases each). If the intrahepatic bile duct super-selective intubation was not successful in 5 min, exchanged another method to do the intubation. The time of intrahepatic bile duct super-selective intubation, the success rate of intubation, and the change of body temperature and serum bilirubin in patients after operation were observed.? Results There were 30 cases intubated successfully in 5 min in the 50 cases patients of zebra guidewire, and the rest cases were successful in 5 min afther changed the angiographic guidewire. All the 50 cases in loach guidewire group intubated successfully in 5 min. Compared with zebra guidewire group, the loach guidewire group had a shorter intubation time［(83.34±11.79)s vs (349.32±43.40)s, P＜0.01], and a higher success rate of intubation(100.00% vs 60.00%, P＜0.01).? Conclusion Compared with zebra guidewire, loach guidewire as angiography shorten the intubation time and improve the success rate of intrahepatic bile duct super-selective intubation.