Abstract:Objective To investigate the application and effect of different occluders in transthoracic ultrasound-guided interventional occlusion in the treatment of patent ductus arteriosus (PDA).? Methods According to the occlusion method, a total of 72 PDA patients were divided into observation group (Amplatz canine duct occluder, n=43) and control group (coil occluder, n=29). The occlusion effect was compared between two groups.? Results There was no significant difference in successful rate of occlusion in the observation group and the control group (97. 67% vs 89. 66%). The complete closure rate was 95. 33% in the observation group and 79. 31% in control group, respectively. The left atrium diameter (LAD), left ventricular end-diastolic diameter (LVEDD), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular stroke volume (LVSV) in both two group at 1 and 3 month(s) after the operation were significantly lower than those at pre-operation (all P<0.05), but showed no difference between two groups (all P>0.05). The occlusion diameter in observation group was higher than that in control group ［(4. 01±0.86)mm vs (1.72±0.48)mm, P<0.01] . There were no significant differences in surgery time and occlusion operation time intra-operationly and in level of pulmonary artery systolic pressure, mean pulmonary artery pressure, aortic pressure and total incidence complications in two groups post-operationly.? Conclusion Both Amplatz canine duct occluder and coil occluder has a good effect in PDA closure which should be chosen according to clinical condition.