Abstract:Objective To investigate the risk factors of lymph node metastasis in clinical stage Ⅰ non-small-cell lung cancer (NSCLC) to provide a basis for evaluating the risk of lymph node metastasis.? Methods Retrospective analysis was made on the clinical data of 305 patients with stage ⅠNSCLC including gender, age, tumor size, tumor differentiation degree who receiving pulmonary lobectomy and systemic lymphadenectomy between December 2014 and December 2016. The patients without node metastasis were served as control group (n=207), and the patients with node metastasis were served as observation group (n=98 ). Logistic regression model was used to analyze the risk factors of lymph node metastasis.? Results Univariate logistic regression analysis revealed that age (P=0.017), gender(P=0.041), pathological feature (P=0.006) , tumor diameter (P<0.001), tumor differentiation degree (P=0.002) , bronchus invasion (P=0.001) , vessel carcinoma embolus (P＜0.001) and nerve invasion (P＜0.001) were the influence factors of lymph node metastasis in clinical stage ⅠNSCLC. Multivariate logistic regression analysis showed that age less than 63 years (P=0.002), tumor diameter >2.0 cm (P=0.004), tumor grade Ⅱ+Ⅲ(P=0.007), vessel carcinoma embolus (P=0.006) and nerve invasion (P=0.04) were the independent risk factors of lymph node metastasis.? Conclusion The risk factors of lymph node metastasis in clinical stage Ⅰ NSCLC are more. The patients with smaller age, larger tumor, poor tumor differentiation degree, invasion of vessel and nerve are prone to lymph node metastasis. Pulmonary lobectomy combined with systemic lymphadenectomy should be served as the standard treatment regimen.