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投稿时间：2024-01-08 网络发布日期：2024-12-21
投稿时间：2024-01-08 网络发布日期：2024-12-21
中文摘要: 目的 探讨低密度脂蛋白（LDL）亚型与2型糖尿病（T2DM）合并急性脑梗死(ACI)的关系。方法 回顾性分析2020年10月至2022年12月南京江北医院收治住院的292例T2DM患者的临床资料。根据脑磁共振检查结果将患者分为T2DM未合并ACI组(A组，n=157)与T2DM合并ACI组(B组，n=135)，采用高分辨率聚丙烯酰胺凝胶电泳法与全自动生化分析仪（贝克曼库尔特 AU5800）分别测定两组研究对象各LDL亚型与总胆固醇（TC）的水平，比较传统危险因素下各分组间血脂的差异。使用logistic回归分析T2DM合并ACI的危险因素。结果 B组的LDL2、LDL3、LDL4、LDL5、TC、LDL水平显著高于A组（P＜0.05）；多因素logistic回归分析显示，高龄、高血压、高LDL2、高LDL4是影响T2DM合并ACI的独立危险因素；受试者工作特征（ROC）曲线显示曲线下面积为0.843。结论 相较于单纯T2DM，LDL2、LDL3、LDL4、LDL5水平在T2DM合并ACI中显著升高，同时高水平的LDL2、LDL4可能是T2DM合并ACI的独立危险因素。
Abstract:Objective To investigate the relationship between low density lipoprotein (LDL) subtypes and acute cerebral infarction (ACI) in type 2 diabetes mellitus (T2DM). Methods A retrospective analysis was conducted on 292 T2DM patients admitted to Nanjing Jiangbei Hospital from October 2020 to December 2022. According to the brain magnetic resonance examination results, the patients were divided into T2DM without ACI group (group A,n=157) and T2DM with ACI group (group B,n=135). High resolution polyacrylamide gel electrophoresis and automatic biochemical analyzer (Beckman AU5800) were used to measure the levels of each LDL subtype and total cholesterol (TC) of the two groups of subjects, and compare the differences of blood lipids among the groups under traditional risk factors. Logistic regression analysis was used to identify risk factors for T2DM combined with ACI. Results The LDL2, LDL3, LDL4, LDL5, TC, LDL in group B were significantly higher than those in group A (P＜0.05). Multivariate logistic regression analysis showed that elder age, hypertension, high levels of LDL2 and LDL4 were independent risk factors for T2DM complicated with ACI; The ROC curve showed an AUC of 0.843. Conclusion Compared with simple T2DM, the level of LDL2, LDL3, LDL4, and LDL5 are significantly increased in T2DM combined with ACI, and high levels of LDL2 and LDL4 may be independent risk factors for T2DM patients combined with ACI.
keywords: Type 2 diabetes mellitus Acute cerebral infarction Low density lipoprotein, subtype Total cholesterol Hypertension
文章编号： 中图分类号：R587.1 文献标志码：A
基金项目:中国石化南化公司临床医学专项科研项目（ZX20203）
附件
| 作者 | 单位 |
| 张仁和 | 1. 南通大学杏林学院附属南京江北医院检验科，江苏 南京 210048 |
| 袁太蕾 | 1. 南通大学杏林学院附属南京江北医院检验科，江苏 南京 210048 |
| 王玉蓉 | 1. 南通大学杏林学院附属南京江北医院检验科，江苏 南京 210048 |
| 王琰 | 2. 南京医科大学第一附属医院 江苏省人民医院血液内科，江苏 南京 210029 |
引用文本：
张仁和,袁太蕾,王玉蓉,等.2型糖尿病患者低密度脂蛋白亚型水平与急性脑梗死的相关性[J].中国临床研究,2024,37(12):1892-1894,1899.
张仁和,袁太蕾,王玉蓉,等.2型糖尿病患者低密度脂蛋白亚型水平与急性脑梗死的相关性[J].中国临床研究,2024,37(12):1892-1894,1899.