Abstract:Objective To analyze the blood lactate levels and lactate clearance rate in septic patients undergoing continuous renal replacement therapy (CRRT) with different clinical outcomes, and to explore the value of blood lactate levels and lactate clearance rate on the prognosis of such patients. b>Methods A retrospective analysis was conducted on the clinical data of 60 septic patients who received CRRT treatment at Renmin Hospital of Wuhan University from January 2019 to November 2022. Based on discharge survival status, patients were divided into the survival group and the death group. Arterial blood lactate levels and lactate clearance rates were compared after treatment between the two groups. Results Of the 60 patients, 45 survived (75.00%), and 15 died (25.00%). Compared with the survival group, the death group had older age, longer hospital stay, and higher APACHEⅡ and SOFA scores (P<0.05); the death group had a higher respiratory rate, longer CRRT treatment time, and higher admission blood lactate levels, CRP levels, and neutrophil percentage (P<0.05); the blood lactate levels in the death group were higher at 0 and 24 hours after treatment, and the blood lactate clearance rate decreased at 24 and 48 hours after treatment, with statistical significance (P<0.05). Conclusion CRRT is an effective treatment for sepsis. The 48-hour lactate clearance rate has significant prognostic value for septic patients undergoing CRRT.