本文已被：浏览 55次 下载 48次
投稿时间：2024-01-02 网络发布日期：2024-10-20
投稿时间：2024-01-02 网络发布日期：2024-10-20
中文摘要: 目的 探讨回阳汤治疗创伤失血性休克的疗效，为治疗该疾病提供新的可行方案。
方法 回顾性分析2022年3月至2023年12月无锡市第九人民医院重症医学科收治的创伤进行手术后的失血性休克患者40例。以接受标准失血性休克诊疗方案治疗、术后血红蛋白低下的患者给予输血至血红蛋白80 g/L的20例患者为对照组；以在上述治疗基础上联合回阳汤治疗3 d的20例患者为观察组。观察两组血清肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)改善状况，以CK、CK-MB的恢复正常+显著改善+改善定义为总有效，比较两组治疗后的总有效率以及治疗前后中医症候积分。
结果 3 d疗程结束评价，观察组CK水平治疗前高于对照组（P＜0.05），治疗后有下降，但与对照组相比差异无统计学意义(P＞0.05)；两组CK-MB水平治疗前差异无统计学意义（P＞0.05），治疗后观察组显著低于对照组(P＜0.01)。观察组CK-MB的治疗总有效率为85.00%，高于对照组的55.00%（χ2=4.290， P＜0.05）；观察组CK的治疗总有效率为50.00%，略高于对照组的30.00%，但差异无统计学意义（χ2=1.670， P＞0.05）。两组患者治疗后头晕、乏力和肢冷的中医症状积分均低于治疗前(P＜0.01)，且观察组均低于对照组(P＜0.05)。
结论 回阳汤治疗创伤失血性休克的疗效较好，可降低失血性休克后中医症状积分，改善血清CK-MB水平的异常。
Abstract:ObjectiveTo investigate the therapeutic efficacy of Huiyang Decoction on traumatic hemorrhagic shock and to propose a new viable treatment approach for the disease.
Methods A retrospective analysis was performed on a cohort of 40 patients with traumatic injuries who underwent surgical intervention at the Department of Critical Care Medicine, Wuxi Ninth Peoples Hospital Affiliated to Soochow University, from March 2022 to December 2023. A total of 20 patients who received standard hemorrhagic shock treatment and received postoperative blood transfusion to hemoglobin 80 g/L were selected as the control group. A total of 20 patients who were treated with Huiyang decoction for 3 days on the basis of the above treatment were selected as the observation group.The improvement of serum creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) in the two groups was observed. The total effective rate was defined as the recovery + significant improvement + improvement of CK and CK-MB to compare the total effective rate after treatment, and TCM symptom score before and after treatment between two groups.
Results After 3-day treatment, the CK level in the observation group was higher than that in the control group before treatment (P＜0.05), and decreased after treatment, but there was no significant difference compared with the control group (P＞0.05). CK-MB levels showed no significant difference between the two groups before treatment (P＞0.05), and that in the observation group was lower compared with the control group after treatment (P＜0.01). The total effective rate of CK-MB in the observation group was significantly higher than that in the control group(85.00% vs 55.00%, χ2=4.290， P＜0.05). The observation group slightly surpassed control group in the total effective rate of CK，however, there was no statistically significant difference (50.00% vs 30.00%, χ2=1.670, P＞0.05). Following treatment, both groups exhibited a significant reduction in TCM syndrome scores for dizziness, fatigue, and cold limbs compared to pre-treatment(P＜0.01), and the observation group demonstrated lower TCM syndrome scores compared to the control group (P＜0.05).
Conclusion Huiyang Decoction has a beneficial effect on traumatic hemorrhagic shock, and can increase TCM symptom scores and improve abnormalities of serum CK-MB level after hemorrhagic shock.
keywords: Huiyang Decoction Traumatic hemorrhagic shock Chinese medicine Chinese Medicine syndrome score: Creatine kinase Creatine kinase isoenzyme
文章编号： 中图分类号：R459.7 文献标志码：B
基金项目:无锡市卫健委重大科研项目（Z202105）；无锡市双百中青年医疗卫生拔尖人才项目（BJ2023108）
附件
引用文本：
王楠,葛新,刘振峰,等.回阳汤治疗创伤失血性休克的疗效[J].中国临床研究,2024,37(10):1583-1586,1592.
王楠,葛新,刘振峰,等.回阳汤治疗创伤失血性休克的疗效[J].中国临床研究,2024,37(10):1583-1586,1592.