Abstract:Objective To observe the application effects of early cardiac rehabilitation combined with psychological care intervention after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). Methods A total of 108 ACS patients who underwent PCI at the Huai'an First People's Hospital from October 2020 to October 2022 were selected. They were randomly divided into the combined group (routine care + early cardiac rehabilitation + psychological nursing intervention) and the control group (routine care), with 54 patients in each group. The study compared the changes in cardiac function, depression levels, self-management ability, medication adherence, quality of life, and major adverse cardiovascular events (MACE) before and after intervention. Results After intervention, the left ventricular ejection fraction (LVEF) in the combined group was higher than that in the control group. The 6-minute walk distance (6MWD) was longer, and the N-terminal pro-B-type natriuretic peptide (NT-proBNP) was lower in the combined group compared to the control group (P＜0.05). The combined group showed lower scores on the Patient Health Questionnaire-9 (PHQ-9) compared to the control group. Scores of the Coronary Heart Disease Self-Management Scale (CSMS) and Morisky Medication Adherence Scale-8 (MMAS-8) were higher in the combined group (P＜0.05). Physical function, psychological function, social function, and material life state scores were higher in the combined group than in the control group (P＜0.05). The incidence of MACE in the combined group was lower than that in the control group (5.77%? vs 19.23%, χ²=4.308, P=0.038). Conclusion Early cardiac rehabilitation combined with psychological care intervention can improve cardiac function, mental status, self-management ability, medication adherence, and quality of life in ACS patients after PCI, reducing the occurrence of MACE.