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中国临床研究:2024,37(9):1327-1330,1335
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肿瘤微环境在结直肠癌转移中的动态演变过程
(1. 山东中医药大学第一临床医学院,山东 济南 250355;2. 烟台市中医医院肿瘤四科,山东 烟台 264002)
Dynamic evolution process of tumor microenvironment in colorectal cancer metastasis
(1.The First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China;2.Forth Department of Oncology, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264002, China)
摘要
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投稿时间:2024-04-08   网络发布日期:2024-09-21
中文摘要: 在结直肠癌转移过程中,肿瘤微环境与原发肿瘤、继发肿瘤、循环肿瘤细胞、播散性肿瘤细胞之间相互作用,本文介绍了其动态演变过程。肿瘤微环境既可以发挥其宿主防御机制杀灭肿瘤细胞,又会通过微环境的成分及结构的改变帮助肿瘤细胞转移扩散。肿瘤细胞则通过表型转换、分泌细胞因子、细胞休眠等方式完成其侵袭、内渗、循环、外渗及播种过程。
Abstract:In the process of colorectal cancer metastasis, the tumor microenvironment interacts with primary tumors, secondary tumors, circulating tumor cells, and disseminated tumor cells. This article introduces its dynamic evolution process. The tumor microenvironment can not only exert its host defense mechanism to kill cancer cells, but also help cancer cells metastasize and spread through changes in the composition and structure of the microenvironment. Cancer cells complete their invasion, infiltration, circulation, extravasation, and seeding processes through phenotype transformation, secretion of cytokines, and cell dormancy.
文章编号:     中图分类号:R735.3    文献标志码:A
基金项目:国家中医药管理局科技司共建科技项目(GZY-KJS-SD-2023-017);山东省中医药科技项目(2020M132, M-2023096);烟台市科技创新发展计划项目(2021MSGY050)
引用文本:
祖玥,戴玲玲,孟鹏,等.肿瘤微环境在结直肠癌转移中的动态演变过程[J].中国临床研究,2024,37(9):1327-1330,1335.

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