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投稿时间:2023-09-20 网络发布日期:2024-08-20
投稿时间:2023-09-20 网络发布日期:2024-08-20
中文摘要: 目的 分析血清单核细胞趋化蛋白-2(MCP-2)、生长分化因子-15(GDF-15)与重度抑郁症(MDD)患者人格特征的相关性及对自杀意念的影响。方法 选取2022年1月至2023年6月哈尔滨市第一专科医院收治的149例MDD患者作为MDD组,选取同期体检健康的志愿者75例作为健康组。采用酶联免疫吸附法检测血清MCP-2、GDF-15水平,采用艾森克人格问卷(EPQ)评估人格特征。Pearson法分析血清MCP-2、GDF-15与EPQ评分的相关性。根据有无自杀意念分组,采用多因素logistic回归及受试者工作特征(ROC)曲线分析各因素对MDD患者产生自杀意念的预测价值。结果 MDD组血清MCP-2、GDF-15水平均高于健康组(P<0.05)。149例MDD患者中56例(37.58%)产生自杀意念。HAMD评分高、睡眠质量较差、重度焦虑、有自杀未遂史及血清MCP-2、GDF-15高水平是MDD患者产生自杀意念的独立危险因素(P<0.05)。血清MCP-2、GDF-15单独及联合预测MDD产生自杀意念的AUC分别为0.679、0.675和0.819。结论 MDD患者血清MCP-2、GDF-15水平与MDD患者人格特征关系密切,血清MCP-2、GDF-15升高为MDD患者产生自杀意念的危险因素。
中文关键词: 抑郁症,重度 单核细胞趋化蛋白-2 生长分化因子-15 人格特征 自杀意念
Abstract:Objective To analyze the correlation between serum monocyte chemotactic protein-2 (MCP-2), growth differentiation factor-15 (GDF-15) and personality characteristics of patients with major depressive disorder (MDD) and their effects on suicidal ideation. Methods A total of 149 MDD patients who were admitted to The First Psychiatric Hospital of Harbin from January 2022 to June 2023 were selected as MDD group, and 75 healthy volunteers who underwent physical examination during the same period were selected as healthy group. Enzyme linked immunosorbent assay was used to detect serum levels of MCP-2 and GDF-15, and the personality traits of MDD patients were evaluated using the Eysenck Personality Questionnaire (EPQ). The Pearson method was used to analyze the correlation between serum MCP-2, GDF-15, and EPQ score. Based on the presence or absence of suicidal ideation, multivariate logistic regression and receiver operating characteristic (ROC) curves were used to analyze the predictive value of each factor on suicidal ideation in MDD patients. Results The levels of serum MCP-2 and GDF-15 in MDD group were higher than those in healthy group (P<0.05). Among the 149 MDD patients, 56 cases (37.58%) had suicidal ideation. Higher HAMD score, poor sleep quality, severe anxiety, history of attempted suicide, and higher levels of serum MCP-2 and GDF-15 were independent risk factors for suicidal ideation in MDD patients (P<0.05). The AUC of serum MCP-2, GDF-15 alone and in combination for predicting suicidal ideation in MDD were 0.679, 0.675 and 0.819, respectively. Conclusion The levels of serum MCP-2 and GDF-15 in MDD patients are closely relate to the personality characteristics of MDD patients, higher levels of MCP-2 and GDF-15 are risk factors for suicidal ideation in MDD patients.
keywords: Depressive disorder, major Monocyte chemotactic protein-2 Growth differentiation factor-15 Personality characteristics Suicides ideation
文章编号: 中图分类号:R749.4 文献标志码:A
基金项目:黑龙江省自然科学基金(A20220481)
作者 | 单位 |
许冰岚 | 1. 哈尔滨市第一专科医院精神科,黑龙江 哈尔滨 150000; |
薛斌 | 2. 哈尔滨市第一专科医院康复科,黑龙江 哈尔滨 150000; |
杜熔淦 | 1. 哈尔滨市第一专科医院精神科,黑龙江 哈尔滨 150000; |
范勤毅 | 1. 哈尔滨市第一专科医院精神科,黑龙江 哈尔滨 150000; |
Author Name | Affiliation |
XU Binglan, XUE Bin, DU Ronggan, FAN Qinyi | *Department of Psychiatry, The First Psychiatric Hospital of Harbin, Harbin, Heilongjiang 150000, China |
引用文本:
许冰岚,薛斌,杜熔淦,等.血清单核细胞趋化蛋白-2和生长分化因子-15对重度抑郁症患者自杀意念的影响[J].中国临床研究,2024,37(8):1229-1233.
许冰岚,薛斌,杜熔淦,等.血清单核细胞趋化蛋白-2和生长分化因子-15对重度抑郁症患者自杀意念的影响[J].中国临床研究,2024,37(8):1229-1233.