Abstract:Objective To analyze the correlation between serum monocyte chemotactic protein-2 (MCP-2), growth differentiation factor-15 (GDF-15) and personality characteristics of patients with major depressive disorder (MDD) and their effects on suicidal ideation. Methods A total of 149 MDD patients who were admitted to The First Psychiatric Hospital of Harbin from January 2022 to June 2023 were selected as MDD group, and 75 healthy volunteers who underwent physical examination during the same period were selected as healthy group. Enzyme linked immunosorbent assay was used to detect serum levels of MCP-2 and GDF-15, and the personality traits of MDD patients were evaluated using the Eysenck Personality Questionnaire (EPQ). The Pearson method was used to analyze the correlation between serum MCP-2, GDF-15, and EPQ score. Based on the presence or absence of suicidal ideation, multivariate logistic regression and receiver operating characteristic (ROC) curves were used to analyze the predictive value of each factor on suicidal ideation in MDD patients. Results The levels of serum MCP-2 and GDF-15 in MDD group were higher than those in healthy group (P＜0.05). Among the 149 MDD patients, 56 cases (37.58%) had suicidal ideation. Higher HAMD score, poor sleep quality, severe anxiety, history of attempted suicide, and higher levels of serum MCP-2 and GDF-15 were independent risk factors for suicidal ideation in MDD patients (P＜0.05). The AUC of serum MCP-2, GDF-15 alone and in combination for predicting suicidal ideation in MDD were 0.679, 0.675 and 0.819, respectively. Conclusion The levels of serum MCP-2 and GDF-15 in MDD patients are closely relate to the personality characteristics of MDD patients, higher levels of MCP-2 and GDF-15 are risk factors for suicidal ideation in MDD patients.