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投稿时间:2024-05-10 网络发布日期:2024-08-20
投稿时间:2024-05-10 网络发布日期:2024-08-20
中文摘要: 目的 分析达格列净对2型糖尿病肾病患者血糖水平、肾功能及miR-21-5p、miR-423-5p水平的影响。方法 选择2022年2月至2023年10月安徽医科大学附属合肥医院收治的98例糖尿病肾病患者,根据随机数表法分为对照组(n=49)与观察组(n=49)。对照组接受二甲双胍治疗,观察组采取二甲双胍+达格列净治疗。对比两组治疗前后血糖水平、肾功能、血清促炎因子水平及miR-21-5p、miR-423-5p表达水平,同时记录两组不良反应发生情况结果 两组治疗3个月后空腹血糖、糖化血红蛋白、肌酐、尿素氮、胱抑素C水平均低于治疗前,且观察组低于对照组(P<0.05);两组治疗3个月后miR-21-5p、miR-423-5p水平及C反应蛋白、肿瘤坏死因子-α、白介素6均低于治疗前,且观察组低于对照组(P<0.05)。观察组和对照组不良反应发生率差异无统计学意义(12.24% vs 6.12%, P>0.05)。结论 达格列净有助于改善糖尿病肾病患者的血糖水平及肾功能,降低miR-21-5p、miR-423-5p表达和血清促炎因子水平,安全性好。
Abstract:ObjectiveTo analyze the effects of dapagliflozin on blood glucose levels, renal function, and the levels of miR-21-5p and miR-423-5p in patients with diabetic nephropathy. Methods A total of 98 patients with diabetic nephropathy admitted in The Second People's Hospital of Hefei from February 2022 to October 2023 were selected and divided into the control group (n=49) and the observation group (n=49) according to the random number table method. The control group was treated with metformin, and the observation group was treated with a combination of metformin and dapagliflozin. Blood glucose levels, renal function, expression levels of miR-21-5p, miR-423-5p and serum proinflammatory factors before and after treatment were compared between the two groups, and the incidence of adverse reactions was recorded. Results The levels of fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and serum creatinine (Scr), blood urea nitrogen (BUN), cystatin C (Cys-C) in both groups decreased after 3 months of treatment, and the above indexes in the observation group were lower than those in the control group (P<0.05). Similarly, levels of miR-21-5p, miR-423-5p, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were significantly lower in the observation group compared to the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (12.24% vs 6.12%, P>0.05). Conclusion Daglipzin can help improve the blood sugar level and renal function of patients with diabetes nephropathy, reduce the expression of miR-21-5p, miR-423-5p and the level of serum proinflammatory factors, with good safety.
keywords: Type 2 diabetic mellitus Diabetic nephropathy Daglipzin Metformin Blood glucose Renal function miR-21-5p miR-423-5p
文章编号: 中图分类号:R587.1 文献标志码:A
基金项目:安徽省卫生健康科研项目(AHWJ2023BAc20099)
作者 | 单位 |
马婷婷 | 1. 合肥市第二人民医院 安徽医科大学附属合肥医院肾内科,安徽 合肥 230000; |
刘莉 | 1. 合肥市第二人民医院 安徽医科大学附属合肥医院肾内科,安徽 合肥 230000; |
徐萍 | 1. 合肥市第二人民医院 安徽医科大学附属合肥医院肾内科,安徽 合肥 230000; |
单亮 | 2. 合肥市第二人民医院 安徽医科大学附属合肥医院药剂科,安徽 合肥 230000 |
Author Name | Affiliation |
MA Tingting, LIU Li, XU Ping, SHAN Liang | *Department of Nephrology, The Second People's Hospital of Hefei, Hefei, Anhui 230000, China |
引用文本:
马婷婷,刘莉,徐萍,等.达格列净对糖尿病肾病患者肾功能及miR-21-5p和miR-423-5p水平的影响[J].中国临床研究,2024,37(8):1219-1223.
马婷婷,刘莉,徐萍,等.达格列净对糖尿病肾病患者肾功能及miR-21-5p和miR-423-5p水平的影响[J].中国临床研究,2024,37(8):1219-1223.