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投稿时间：2024-02-19 网络发布日期：2024-08-20
投稿时间：2024-02-19 网络发布日期：2024-08-20
中文摘要: 术后谵妄（POD）是老年患者手术后常见的一种并发症，严重影响患者的预后，增加病死率。POD的发病机制目前仍未明确，其危险因素繁杂，预防困难，治疗效果不佳。艾司氯胺酮是一种高亲和性的N-甲基-D-天冬氨酸(NMDA)受体非竞争性抑制药，同时具备麻醉和镇痛作用，除了广泛应用于围术期麻醉诱导与维持、急慢性疼痛的治疗与管理外，艾司氯胺酮在精神疾病和急危重症诊疗等多学科领域同样有较好的临床应用。本文将近年来国内外应用艾司氯胺酮防治POD的作用机制和研究进展进行综述，为临床提供新的思路。
Abstract:Postoperative delirium (POD) is a common complication in elderly patients after surgery, significantly affecting prognosis and increasing mortality rates. The underlying mechanisms of POD remain unclear, with diverse risk factors making prevention difficult and treatment outcomes unsatisfactory. Esketamine is a high-affinity N-methyl-D-aspartate (NMDA) receptor antagonist known for its anesthetic and analgesic properties. Besides its widespread use in perioperative anesthesia and pain management, esketamine has shown promising clinical applications across various disciplines including psychiatry and critical care. This review summarizes recent advances and mechanisms of esketamine in preventing and treating POD, offering new insights for clinical practice.
keywords: Esketamine Postoperative delirium Elderly patients Mental illness Induction of anesthesia Pain treatment Pain management
文章编号： 中图分类号：R614 文献标志码：A
基金项目:青海省科技计划项目（2019-ZJ-7085）；青海省卫生健康系统重点课题（2023-wjzdx-86）
| Author Name | Affiliation |
| GAO Shilong, ZHANG Peifu, WANG Enqiang, WANG Qifang, YAO Zeyu | Department of Anesthesia, Qinghai Red Cross Hospital, Xining, Qinghai 810000, China |
引用文本：
高世龙，张培福，王恩强，王启芳，姚泽宇.艾司氯胺酮与术后谵妄的研究进展[J].中国临床研究,2024,37(8):1164-1167.
高世龙，张培福，王恩强，王启芳，姚泽宇.艾司氯胺酮与术后谵妄的研究进展[J].中国临床研究,2024,37(8):1164-1167.