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投稿时间：2024-06-07 网络发布日期：2024-07-20
投稿时间：2024-06-07 网络发布日期：2024-07-20
中文摘要: 目的 探讨在自然人群中，三酰甘油—葡萄糖（TyG）指数与动脉硬化有无相关性，TyG指数能否作为心脑血管疾病不良预后的预测因素。
方法 横断面分析4 355例2009年至2010年于江苏省高邮市社区收集到的自然人群数据。根据TyG指数四分位数进行分组：Q1组（TyG≤8.19，n=1 100），Q2组（8.19＜TyG≤8.55，n=1 080)，Q3组（8.55＜TyG≤8.99，n=1 103)，Q4组（TyG＞8.99，n=1 072)。以肱踝脉搏波传导速度（baPWV）为动脉硬化观测指标，通过单因素和多因素线性回归分析TyG指数与baPWV的相关性。多因素校正的限制性立方样条函数图探究TyG指数与baPWV是否存在非线性相关。
结果 校正混杂因素后，与Q1组对比，TyG指数在Q2、Q3、Q4组间影响baPWV的回归系数及其95%CI分别为0.11(-0.07~0.29)、0.41(0.23~0.59)、0.97(0.78~1.16)（趋势检验P＜0.01）。限制性立方样条函数分析显示，TyG指数与baPWV呈线性正相关。中介效应分析显示TyG指数通过炎症部分介导了对baPWV的影响。
结论 TyG指数与动脉硬化呈线性正相关。
中文关键词: 三酰甘油—葡萄糖指数 动脉硬化 肱踝脉搏波传导速度 中介效应
Abstract:Objective To explore the correlation between triglyceride glucose (TyG) index and arteriosclerosis in natural population, and whether TyG index could be used as a predictor of poor prognosis of cardio-cerebrovascular diseases.
Methods A cross-sectional study was conducted on 4 355 adults recruited from the natural population in the community of Gaoyou City, Jiangsu Province from 2009 to 2010. According to the TyG index quartiles, they were divided into Q1 group (TyG≤8.19,n=1 100), Q2 group (8.19＜TyG≤8.55,n=1 080), Q3 group (8.55＜TyG≤8.99,n=1 103), Q4 group (TyG＞8.99,n=1 072). Taking brachial-ankle pulse wave conduction velocity (baPWV) as the observation index of arteriosclerosis, the correlation between TyG index and baPWV was analyzed by univariate and multivariate linear regression. A restricted cubic spline function diagram with multivariate correction was performed to explore whether there was a nonlinear correlation between TyG index and baPWV.
Results After adjusting for confounding factors, compared with Q1 group, the regression coefficient and its 95%CI of TyG index affecting baPWV among Q2, Q3 and Q4 groups were 0.11 (-0.07-0.29), 0.41 (0.23-0.59) and 0.97 (0.78-1.16), respectively (trend testP＜0.01). Restricted cubic spline analysis showed a linear positive correlation between TyG index and baPWV. The mediator effect analysis also showed that TyG index partially mediated the impact on baPWV through inflammation.
Conclusion TyG index is linearly and positively correlated with atherosclerosis.
keywords: Triglyceride glucose index Arteriosclerosis Brachial ankle pulse wave conduction velocity Mediator effect
文章编号： 中图分类号：R587.2 文献标志码：A
基金项目:江苏省医学重点学科/实验室项目（ZDXK202202）
引用文本：
孔祥萦,廖深根,李玥 ,等.三酰甘油—葡萄糖指数与动脉硬化的相关性[J].中国临床研究,2024,37(7):1018-1021.
孔祥萦,廖深根,李玥 ,等.三酰甘油—葡萄糖指数与动脉硬化的相关性[J].中国临床研究,2024,37(7):1018-1021.