Abstract:Objective To investigate the surgical treatment effect of hepatocellular carcinoma (HCC) combined with bile duct tumor thrombus and the impact of Satoh classification on patient prognosis. Methods The clinical data of 29 patients with HCC combined with bile duct tumor thrombus who underwent radical surgery (anatomical liver resection/irregular liver resection + bile duct incision and embolectomy) in the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University from January 2010 to October 2016 were retrospectively analyzed. According to Satoh classification, there were 9 cases of type Ⅰ, 6 cases of type Ⅱ, and 14 cases of type Ⅲ. Results All 29 patients successfully completed the operation, with perioperative death in 1 case (type Ⅲ) and loss to follow-up in 1 case (type Ⅱ). The overall 1-year and 3-year survival rates of patients after surgery were 60.7% and 53.6%, respectively. The 1-year disease-free survival rates of types Ⅰ, Ⅱ, and Ⅲ were 6/9, 3/5, and 6/14, respectively, and the 3-year disease-free survival rates were 5/9, 2/5, and 3/14, respectively. Conclusion For HCC patients combined with bile duct tumor thrombus, active anatomical liver resection/irregular liver resection + bile duct incision and embolectomy can achieve good surgical results. Satoh classification has certain guiding significance for judging patient prognosis.