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投稿时间：2024-02-06 网络发布日期：2024-05-20
投稿时间：2024-02-06 网络发布日期：2024-05-20
中文摘要: 脊髓损伤具有高致死率与高致残率的特点，其治疗一直是世界性难题。随着脊髓损伤研究的深入和治疗手段的进步，脊髓损伤患者的生存率有所提升，但其预后仍不理想。最新研究发现，免疫反应参与脊髓损伤后的病理变化和再生修复全过程，其中，补体系统在脊髓损伤的发生发展中扮演了重要角色。本文主要综述补体系统在继发性脊髓损伤及脊髓损伤后再生修复中的作用，包括补体系统的双刃剑作用，补体系统影响轴突再生与突触维持，及可能存在的信号通路，以期为脊髓损伤患者提供新的治疗思路。
Abstract:Spinal cord injury has the characteristics of high mortality and disability rates, and the treatment of spinal cord injury has been a worldwide problem. With the deepening of spinal cord injury research and the advancement of treatment methods, the survival rate of patients has improved, but the clinical efficacy is still not ideal. New research has found that the immune response is involved in the entire process of pathological changes and regeneration and repair after spinal cord injury. Among them, the complement system plays an important role in the occurrence and development of spinal cord injury. This article mainly reviews the role of the complement system in secondary spinal cord injury and regeneration and repair after spinal cord injury, including the double edged sword effect of the complement system, the impact of the complement system on axonal regeneration and synaptic maintenance, and possible signaling pathways, with a view to improving the treatment of spinal cord injury, providing new treatment ideas.
文章编号： 中图分类号：R745.4 文献标志码：A
基金项目:徐州市卫生健康委彭城英才—医学青年后备人才项目（XWRCHT20220035）；徐州市卫生健康委医学科技创新重点项目（XWKYHT20230055）
附件
| Author Name | Affiliation |
| ZHANG Jiacheng*, YE Shuang, LI Congwen, XUE Huai, XU Tie, LIU Xiao | *Xuzhou Medical University, Xuzhou, Jiangsu 221004, China |
引用文本：
张家诚,叶双,李从文,等.补体系统在脊髓损伤后神经修复中的作用进展[J].中国临床研究,2024,37(5):670-673.
张家诚,叶双,李从文,等.补体系统在脊髓损伤后神经修复中的作用进展[J].中国临床研究,2024,37(5):670-673.