Abstract:Peri-pancreatic fluid collection (PFC) is mainly caused by acute pancreatitis, chronic pancreatitis, pancreatic trauma and surgery. Most of PFC could be treated conservatively and absorbed by itself. However, PFC that causes clinical symptoms requires treatment, including percutaneous drainage, endoscopic treatment, and surgery. By the continuous development of endoscopic technology and accessories in recent years, endoscopic treatment has become the first-line treatment for PFC, including endoscopic drainage and endoscopic necrosectomy. The present article would combine the latest research and clinical experience, and classify the unique advantages of endoscopic treatment in the PFC management from the perspectives of endoscopic diagnosis, endoscopic intervention indications, endoscopic drainage, endoscopic debridement and related complications.