Abstract:Objective To evaluate ultrasound guided cervical nerves pathway block (CNPB) for internal jugular vein cannulation in awake patients. Methods A total of 100 patients who underwent elective jugular vein puncture and catheterization at Nanjing Pukou District Hospital of Chinese Medicine from June to December 2021 were selected and divided into ultrasound guided CNPB group (group B, n=50) and local infiltration anesthesia group (group C, n=50). Both groups underwent internal jugular vein catheterization under ultrasound guidance. The outcome indicators were the Numeric Rating Scales (NRS), Bruggrmann Comfort Scale (BCS), hemodynamic parameters, sleeping quality, and the complications. The results were recorded in the morning of the cannulation operation (T0), during the operation (T1), 5 min after the cannulation (T2), that night of the cannulation (T3), postoperative day 1 (T4), postoperative day 2 (T5). Results The NRS of group B were significantly lower than that of group C at T1 and T3. The BCS of group B were higher than group C at T1, T2, T3, and T4. The heart rate and systolic blood pressure at T1 in group B were dramatically lower than group C. At T3 and T4, sleeping quality of group B was better than group C (P＜0.05). Conclusion Ultrasound guided CNPB, as the anesthesia for internal jugular vein cannulation in awake patients, can effectively reduce the NRS scaling and improve the BCS and sleeping quality without obvious adverse reactions.