Abstract:Objective To compare the advantages and disadvantages of two different resection margins by observing the clinical efficacy of laparoscopic total gastrectomy (TG) and proximal gastrectomy(PG) for radical resection of adenocarcinoma of esophagogastric junction (AEJ). Methods A total of 90 patients with AEJ who were treated by Huai ‘an No.1 People ‘s Hospital from January 2020 to December 2021 were retrospectively reviewed. Patients were divided into PG group ( n=43) and TG group ( n=47) according to the surgical resection range. The general data, surgery related statistical indicators of the two groups were compared. Results The TG group had a longer operation time than the PG group, with significantly more intraoperative blood loss and a greater number of intraoperatively cleared lymph nodes than the PG group (P＜0.05). There was no significant difference in terms of drainage volume of the abdominal drainage tubes in the 3 day postoperative period, postoperative period to the drainage removal, the length of hospitalization, and postoperative complications between two groups (P>0.05). Postoperative levels of hemoglobin, albumin, and prealbumin were significant lower in TG group compared with those in PG group (P<0.05). The 1 year overall survival rates for the PG group and TG group were 95.3% and 87.2%, respectively, and the difference was not statistically significant (P＞0.05 ). Conclusion Compared with TG, PG is more conducive to the absorption of nutrients and the recovery of nutritional status after surgery, and it is also important to take optimal reconstruction methods to reduce reflux in patients. 